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OriGene shRNA Recent Citations

RNA interference-mediated in vivo silencing of FasL as a strategy for the enhancement of DNA vaccine potency, Human Gene Therapy. August 2008, 19(8): 763-773 [sh-Luc(in vivo application)]


Suppression of Sproutys Has a Therapeutic Effect for a Mouse Model of Ischemia by Enhancing Angiogenesis, Koji Taniguchi, Ken-ichiro Sasaki, Kousuke Watari, Hideo Yasukawa, Tsutomu Imaizumi, Toranoshin Ayada, Fuyuki Okamoto, Takuma Ishizaki,Reiko Kato,Ri-ichiro Kohno,Hiroshi Kimura,Yasufumi Sato,Mayumi Ono,Yoshikazu Yonemitsu,and Akihiko Yoshimura, PLoS ONE. 2009; 4(5): e5467 [Spry4(in vivo application)]


MicroRNA-98 and let-7 Confer Cholangiocyte Expression of Cytokine-Inducible Src Homology 2-Containing Protein in Response to Microbial Challenge, J. Immunol., Aug 2009; 183: 1617 - 1624 [CISH]


[6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A4 Hydrolase, Cancer Res., Jul 2009; 69: 5584 - 5591 [LTA4H]


Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4, Cancer Res., Jul 2009; 69: 5743 - 5751. [RGS4]


DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair, Mol. Cell. Biol., Jul 2009; 29: 3597 - 3604 [TRF2]


Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK, Cellular Signalling, Volume 21, Issue 7, July 2009, Pages 1207-1217 [RALa]


All Citations click here

 

Home Antibody KO Validated Antibodies

Knockout (KO) Validation

OriGene employs CRISPR to validate antibody specificity

KO-Validated-Antibody

Why KO validation?

Specificity has been a major unsolved issue for antibody application. OriGene has been a pioneer in providing highly validated antibodies. Using KO lysate is OriGene’s second initiative after UltraMAB, which utilize high-density protein arrays (17K protein chip) to validated antibody specificity.

Western blot using knockout (KO) cell lysate has become a new practice for antibody validation. In KO validation, a knockout cell line was paired with the parental cell line in western blot analysis. A truly specific antibody recognizes the target protein of right molecular weight in the WT cell lysate, but not in the KO cell lysate.


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Featured knockout (KO) validated antibodies

Knockout cell lysates

CRISPR technology has accelerated the generation of KO cell lines. Teaming up with EdiGene, OriGene is now offering a growing list of KO cell lysates. Not only we utilize the KO lysate for validation of OriGene’s antibodies, we also offer them to research community, to be used as WB negative controls.

Furthermore, OriGene offers the largest collection of Tagged Over-expression Lysates, providing a cost-effective option as positive control in Western blot, ELISA and other antibody assays.


 

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