Il2 Rat Monoclonal Antibody [Clone ID: I2-C7]

Specifications

Product Data
Clone Name	I2-C7
Applications	FN
Recommend Dilution	A 1:50 dilution will block 50 - 70% of CTLL proliferative response to 5% Con A sup as a source for mouse IL-2. This antibody will also block 50 - 70% of MLR or T cell proliferation to KLH
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Mouse IL-2 purified from Con A activated T cell supernatant
Specificity	This antibody reacts to IL-2. Does not cross react with rat or human IL-2.
Formulation	PBS State: Azide Free State: Lyophilized purified Ig
Reconstitution Method	Restore with 0.2ml water. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Concentration	lot specific
Purification	Protein A/S-Sepharose
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	interleukin 2
Database Link	Entrez Gene 16183 Mouse UniProt ID P04351
Background	Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.
Synonyms	IL-2, TCGF
Reference Data

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