SIRT1 (456-555) Mouse Monoclonal Antibody [Clone ID: 7B7]

Specifications

Product Data
Clone Name	7B7
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA. Immunofluorescence: 10 µg/ml. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant protein, SIRT1 (AAH12499, 456 a.a. ~ 555 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity	This antibody reacts to Sirtuin-1 (SIRT1)at aa 456-555.
Formulation	PBS, pH 7.4 State: Liquid purfied Ig fraction
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	sirtuin 1
Database Link	Entrez Gene 23411 Human UniProt ID Q96EB6
Background	The SIRT family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes including transcriptional regulation, cell cycle progression, DNA damage repair and aging. Sirtuins utilize NAD+ as a substrate to catalyze deacetylation of specific acetylated protein and histones. SIRT1 has been shown to be induced by caloric restriction (CR) in several tissues and SIRT1 mediated deacetylase activity attenuates B-amyloid content in the brain during CR. SIRT1 also regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53.
Synonyms	SIRT-1, SIR2-like protein 1, SIR2L1, sirtuin type 1, sirtuin 1, sirtuin-1, SIR2alpha
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transcription Factors

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.