CD19 Mouse Monoclonal Antibody [Clone ID: 4G7]

Specifications

Product Data
Clone Name	4G7
Applications	FC
Recommend Dilution	Indirect immunofluorescence analysis by Flow Cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human CCL (chronic lymphocytic leukemia) cells
Specificity	The mouse monoclonal antibody 4G7 recognizes CD19 (B4), a 95 kDa type I transmembrane glycoprotein of immunoglobulin superfamily, expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells.
Formulation	PBS Label: Biotin State: Liquid purified Ig fraction Preservative: 15 mM sodium azide Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store at 2-8°C. Do not freeze.
Gene Name	CD19 molecule
Database Link	Entrez Gene 930 Human UniProt ID P15391
Background	CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
Synonyms	Leu-12, B-cell marker
Reference Data

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