TIM 4 (TIMD4) Rabbit Polyclonal Antibody

CAT#: AP07363PU-N

TIM 4 (TIMD4) rabbit polyclonal antibody, Aff - Purified



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CNY 5,654.00


货期*
5周

规格
    • 50 ug

Product images

Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution Immunocytochemistry.
Immunofluorescence.
Immunohistochemistry on Frozen Sections.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 1 - 2 µg/ml.
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide - KLH conjugated corresponding to a 16 amino acid peptide from near the center of Human TIM-4
Specificity This antibody recognizes T-cell Immunoglobulin And Mucin Domain Containing 4 (TIMD4)
Formulation PBS containing 0.02% Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified IgG fraction.
Concentration lot specific
Purification Immunoaffinity Chromatography.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or in aliquots at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name T-cell immunoglobulin and mucin domain containing 4
Background The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. Studies have shown that TIM 4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM 1, and that this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM 4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain (Kuchroo et al, 2003). The TIM 4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM 1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma (Shakhov et al 2004).
Synonyms TIMD-4, TIM4, TIM-4, T-cell membrane protein 4
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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