Caveolin 1 (CAV1) Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:8,000. WB: 0.01-0.03ug/ml
Reactivity	Human, Mouse, Rat, Dog, Pig
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-DELSEKQVYDAH, from the internal region of the protein sequence according to NP_001744.2.
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	20.3 kDa
Gene Name	caveolin 1
Database Link	NP_001744 Entrez Gene 12389 MouseEntrez Gene 25404 RatEntrez Gene 403980 DogEntrez Gene 857 Human UniProt ID Q03135
Background	The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. [provided by RefSeq]
Synonyms	BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Focal adhesion, Viral myocarditis

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