Dectin 1 (CLEC7A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	CLEC7A antibody was raised against a 17 amino acid synthetic peptide near the center of human CLEC7A.
Formulation	CLEC7A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	CLEC7A Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	C-type lectin domain family 7 member A
Database Link	NP_922938 Entrez Gene 64581 Human UniProt ID Q9BXN2
Background	CLEC7A Antibody: CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
Synonyms	BGR; CANDF4; CD369; CLECSF12; DECTIN1; SCARE2
Reference Data

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