KCNA5 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse spleen tissue
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 517-613 amino acids of human potassium voltage-gated channel, shaker-related subfamily, member 5
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	44 kDa
Gene Name	potassium voltage-gated channel subfamily A member 5
Database Link	NP_002225 Entrez Gene 16493 MouseEntrez Gene 25470 RatEntrez Gene 3741 Human UniProt ID P22460
Background	Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release; heart rate; insulin secretion; neuronal excitability; epithelial electrolyte transport; smooth muscle contraction; and cell volume. Four sequence-related potassium channel genes - shaker; shaw; shab; and shal - have been identified in Drosophila; and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel; voltage-gated; shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class; the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless; and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7).?
Synonyms	ATFB7; HCK1; HK2; HPCN1; KV1.5; PCN1
Reference Data
Protein Families	Druggable Genome, Ion Channels: Potassium, Transmembrane

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