MMP11 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Human colon and ovarian cancer tissue IHC: 50-200 Positive control: Human lung cancer Predicted cell location: Cytoplasm, ExtraCellular matrix
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 470-488 amino acids of Human matrix metallopeptidase 11 (stromelysin 3)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	55 kDa
Gene Name	matrix metallopeptidase 11
Database Link	NP_005931 Entrez Gene 17385 MouseEntrez Gene 4320 Human UniProt ID P24347
Background	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes; such as embryonic development; reproduction; and tissue remodeling; as well as in disease processes; such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However; the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's; this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
Synonyms	SL-3; ST3; STMY3
Reference Data
Protein Families	Druggable Genome, Protease

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