Annexin A1 (ANXA1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, WB
Recommend Dilution	WB 1:500 - 1:2000;IF 1:50 - 1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human ANXA1
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	annexin A1
Database Link	NP_000691 Entrez Gene 16952 MouseEntrez Gene 25380 RatEntrez Gene 301 Human UniProt ID P04083
Background	The annexin superfamily consists of 13 calcium or calcium and phospholipid binding proteins with high biological and structural homology . Annexin-1 (ANXA1) is the first characterized member of the annexin family of proteins and is able to bind to cellular membranes in a calcium-dependent manner, promoting membrane fusion and endocytosis . Annexin A1 has anti-inflammatory properties and inhibits phospholipase A2 activity . Annexin A1 can accumulate on internalized vesicles after EGF-stimulated endocytosis and may be required for a late stage in inward vesiculation . Phosphorylation by PKC, EGFR, and Chak1 results in inhibition of annexin A1 function . Annexin A1 has also been identified as one of the eat-me signals on apoptotic cells that are to be recognized and ingested by phagocytes . Annexin A1, as an endogenous anti-inflammatory mediator, has roles in many diverse cellular functions, such as membrane aggregation, inflammation, phagocytosis, proliferation, apoptosis, and tumorigenesis and cancer development .
Synonyms	ANX1; LPC1
Reference Data
Protein Families	Druggable Genome

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