MCK10 (DDR1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000~1:2000
Reactivity	Human, Rat, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human CD167a.
Specificity	CD167a polyclonal antibody detects endogenous levels of CD167a protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 95 kDa
Gene Name	discoidin domain receptor tyrosine kinase 1
Database Link	Entrez Gene 780 Human UniProt ID Q08345
Background	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing.
Synonyms	CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE; CD167 antigen-like family member A; Cell adhesion kinase; DDR1; Discoidin receptor tyrosine kinase; Epithelial discoidin domain-containing receptor 1; Epithelial discoidin domain receptor 1; HGK2; Mammary carcinoma kinase 10; MCK-10; Protein-tyrosine kinase 3A; Protein-tyrosine kinase RTK-6; TRK E; Tyrosine-protein kinase CAK; Tyrosine kinase DDR
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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