ZSWIM8 (NM_015037) Human 3' UTR Clone

Specifications

Product Data
Product Name	ZSWIM8 (NM_015037) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	KIAA0913
ACCN	NM_015037
Insert Size	304 bp
Sequence Data	Insert Sequence (showhide) >SC203760 3’UTR clone of NM_015037 The sequence shown below is from the reference sequence of NM_015037. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCACTCGAGATGGCCACCTTCTCCCCCTGAGTCTTTCACCCTTAGGGTCCTATACAGGGACCCAGGCCT GTGGCTATGGGGGCCCCTCACACAGGGGGAGTGAAACTTGGCTGGACAGATCATCCTCACTCAGTTCCC TGGTAGCACAGACTGACAGCTGCTCTTGGGCTATAGCTTGGGGCCAAGATGTCTCACACCCTAGAAGCC TAGGGCTGGGGGAGACAGCCCTGTCTGGGAGGGGGCGTTGGGTGGCCTCTGGTATTTATTTGGCATTTA TAAATATATAAACTCCTTTTTTACTCTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_015037.4
Synonyms	KIAA0913
Summary	Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also acts as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004).[UniProtKB/Swiss-Prot Function]
Locus ID	23053
MW	11

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