ORP150 (HYOU1) (NM_006389) Human 3' UTR Clone

Specifications

Product Data
Product Name	ORP150 (HYOU1) (NM_006389) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	GRP-170; Grp170; HSP12A; IMD59; ORP-150; ORP150
ACCN	NM_006389
Insert Size	1435 bp
Sequence Data	Insert Sequence (showhide) >SC214544 3’UTR clone of NM_006389 The sequence shown below is from the reference sequence of NM_006389. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAGCGGCCTTTGAAGAACGACGAACTATAACCCCCACCTCTGTTTTCCCCATTCATCTCCACCCCCTTC CCCCACCACTTCTATTTATTTAACATCGAGGGTTGGGGGAGGGGTTGGTCCTGCCCTCGGCTGGAGTTC CTTTCTCACCCCTGTGATTTGGAGGTGTGGAGAAGGGGAAGGGAGGGACAGCTCACTGGTTCCTTCTGC AGTACCTCTGTGGTTAAAAATGGAAACTGTTCTCCTCCCCAGCCCCACTCCCTGTTCCCTACCCATATA GGCCCTAAATTTGGGAAAAATCACTATTAATTTCTGAATCCTTTGCCTGTGGGTAGGAAGAGAATGGCT GCCAGTGGCTGATGGGTCCCGGTGATGGGAAGGGTATCAGGTTGCTGGGGAGTTTCCACTCTTCTCTGG TGATTGTTCCTTCCCTCCCTTCCTCTCCCACCATGCGATGAGCATCCTTTCAGGCCAGTGTCTGCAGAG CCTCAGTTACCAGGTTTGGTTTCTGAGTGCCTATCTGTGCTCTTTCCTCCCTCTGCGGGCTTCTCTTGC TCTGAGCCTCCCTTCCCCATTCCCATCCAGCTCCTTTCCCCCTGGGTTTCCTTGGCTTCCTGCAGCAAA TTGGGCAGTTCTCTGCCCCTTGCCTAAAAGCCTGTACCTCTGGATTGGCGGAAGTAAATCTGGAAGGAT TCTCACTCGTATTTCCCACCCCTAGTGGCCAGAGGAGGGAGGGGCACAGTGAAGAAGGGAGCCCACCAC CTCTCCGAAGAGGAAAGCCACGTAGAGTGGTTGGCATGGGGTGCCAGCATCGTGCAAGCTCTGTCATAA TCTGCATCTTCCCAGCAGCCTGGTACCCCAGGTTCCTGTAACTCCCTGCCTCCTCCTCTCTTCTGCTGT TCTGCTCCTCCCAGACAGAGCCTTTCCCTCACCCCCTGACCCCCTGGGCTGACCAAAATGTGCTTTCTA CTGTGAGTCCCTATCCCAAGATCCTGGGGAAAGGAGAGACCATGGTGTGAATGTAGAGATGCCACCTCC CTCTCTCTGAGGCAGGCCTGTGGATGAAGGAGGAGGGTCAGGGCTGGCCTTCCTCTGTGCATCACTCTG CTAGGTTGGGGGCCCCCGACCCACCATACCTACGCCTAGGGAGCCCGTCCTCCAGTATTCCGTCTGTAG CAGGAGCTAGGGCTGCTGCCTCAGCTCCAAGACAAGAATGAACCTGGCTGTGTCAGTCATTTTGTCTTT TCCTTTTTTTTTTTTTTTTGCCACATTGGCAGAGATGGGACCTAAGGGTCCCACCCCTCACCCCACCCC CACCTCTTCTGTATGTTTGAATTCTTTCAGTAGCTGTTGATGCTGGTTGGACAGGTTTGAGTCAAATTG TACTTTGCTCCATTGTTAATTGAGAAACTGTTTCAATAAAATATTCTTTTCTACA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_006389.5
Synonyms	GRP-170; Grp170; HSP12A; IMD59; ORP-150; ORP150
Summary	The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Locus ID	10525
MW	53.3

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