FBXW7 (NM_001013415) Human 3' UTR Clone

Specifications

Product Data
Product Name	FBXW7 (NM_001013415) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AGO; CDC4; FBW6; FBW7; FBX30; FBXO30; FBXW6; hAgo; hCdc4; SEL-10; SEL10
ACCN	NM_001013415
Insert Size	1645 bp
Sequence Data	Insert Sequence (showhide) >SC215692 3' UTR clone of NM_001013415 The sequence shown below is from the reference sequence of NM_001013415. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC GCTGGACTTTGATGTGGACATGAAGTGAAGAGCAGAAAAGATGAATTTGTCCAATTGTGTAGACGATATA CTCCCTGCCCTTCCCCCTGCAAAAAGAAAAAAAGAAAAGAAAAAGAAAAAAATCCCTTGTTCTCAGTGGT GCAGGATGTTGGCTTGGGGCAACAGATTGAAAAGACCTACAGACTAAGAAGGAAAAGAAGAAGAGATGAC AAACCATAACTGACAAGAGAGGCGTCTGCTGTCTCATCACATAAAAGGCTTCACTTTTGACTGAGGGCAG CTTTGCAAAATGAGACTTTCTAAATCAAACCAGGTGCAATTATTTCTTTATTTTCTTCTCCAGTGGTCAT TGGGCAGTGTTAATGCTGAAACATCATTACAGATTCTGCTAGCCTGTTCTTTTACCACTGACAGCTAGAC ACCTAGAAAGGAACTGCAATAATATCAAAACAAGTACTGGTTGACTTTCTAATTAGAGAGCATCTGCAAC AAAAAGTCATTTTTCTGGAGTGGAAAAGCTTAAAAAAATTACTGTGAATTGTTTTTGTACAGTTATCATG AAAAGCTTTTTTTTTTTTTTTTTTGCCAACCATTGCCAATGTCAATCAATCACAGTATTAGCCTCTGTTA ATCTATTTACTGTTGCTTCCATATACATTCTTCAATGCATATGTTGCTCAAAGGTGGCAAGTTGTCCTGG GTTCTGTGAGTCCTGAGATGGATTTAATTCTTGATGCTGGTGCTAGAAGTAGGTCTTCAAATATGGGATT GTTGTCCCAACCCTGTACTGTACTCCCAGTGGCCAAACTTATTTATGCTGCTAAATGAAAGAAAGAAAAA AGCAAATTATTTTTTTTTATTTTTTTTCTGCTGTGACGTTTTAGTCCCAGACTGAATTCCAAATTTGCTC TAGTTTGGTTATGGAAAAAAGACTTTTTGCCACTGAAACTTGAGCCATCTGTGCCTCTAAGAGGCTGAGA ATGGAAGAGTTTCAGATAATAAAGAGTGAAGTTTGCCTGCAAGTAAAGAATTGAGAGTGTGTGCAAAGCT TATTTTCTTTTATCTGGGCAAAAATTAAAACACATTCCTTGGAACAGAGCTATTACTTGCCTGTTCTGTG GAGAAACTTTTCTTTTTGAGGGCTGTGGTGAATGGATGAACGTACATCGTAAAACTGACAAAATATTTTA AAAATATATAAAACACAAAATTAAAATAAAGTTGCTGGTCAGTCTTAGTGTTTTACAGTATTTGGGAAAA CAACTGTTACAGTTTTATTGCTCTGAGTAACTGACAAAGCAGAAACTATTCAGTTTTTGTAGTAAAGGCG TCACATGCAAACAAACAAAATGAATGAAACAGTCAAATGGTTTGCCTCATTCTCCAAGAGCCACAACTCA AGCTGAACTGTGAAAGTGGTTTAACACTGTATCCTAGGCGATCTTTTTTCCTCCTTCTGTTTATTTTTTT GTTTGTTTTATTTATAGTCTGATTTAAAACAATCAGATTCAAGTTGGTTAATTTTAGTTATGTAACAACC TGACATGATGGAGGAAAACAACCTTTAAAGGGATTGTGTCTATGGTTTGATTCACTTAGAAATTTTATTT TCTTATAACTTAAGTGCAATAAAATGTGTTTTTTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001013415.1
Synonyms	AGO; CDC4; FBW6; FBW7; FBX30; FBXO30; FBXW6; hAgo; hCdc4; SEL-10; SEL10
Summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Locus ID	55294

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