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MLH3 (NM_001040108) Human Tagged ORF Clone
CAT＃: RC221591
- TrueORF®
MLH3 (Myc-DDK-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1
ORF Plasmid: tGFP
"NM_001040108" in other vectors (4)
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CNY 14,540.00
Product images
CNY 300.00
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | HNPCC7 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RC221591 representing NM_001040108
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGATCAAGTGCTTGTCAGTTGAAGTACAAGCCAAATTGCGTTCTGGTTTGGCCATAAGCTCCTTGGGCC AATGTGTTGAGGAACTTGCCCTCAACAGTATTGATGCTGAAGCAAAATGTGTGGCTGTCAGGGTGAATAT GGAAACCTTCCAAGTTCAAGTGATAGACAATGGATTTGGGATGGGGAGTGATGATGTAGAGAAAGTGGGA AATCGTTATTTCACCAGTAAATGCCACTCGGTACAGGACTTGGAGAATCCAAGGTTTTATGGTTTCCGAG GAGAGGCCTTGGCAAATATTGCTGACATGGCCAGTGCTGTGGAAATTTCGTCCAAGAAAAACAGGACAAT GAAAACTTTTGTGAAACTGTTTCAGAGTGGAAAAGCCCTGAAAGCTTGTGAAGCTGATGTGACTAGAGCA AGCGCTGGGACTACTGTAACAGTGTATAACCTATTTTACCAGCTTCCTGTAAGGAGGAAATGCATGGACC CTAGACTGGAGTTTGAGAAGGTTAGGCAGAGAATAGAAGCTCTCTCACTCATGCACCCTTCCATTTCTTT CTCTTTGAGAAATGATGTTTCTGGTTCCATGGTTCTTCAGCTCCCTAAAACCAAAGACGTATGTTCCCGA TTTTGTCAAATTTATGGATTGGGAAAGTCCCAAAAGCTAAGAGAAATAAGTTTTAAATATAAAGAGTTTG AGCTTAGTGGCTATATCAGCTCTGAAGCACATTACAACAAGAATATGCAGTTTTTGTTTGTGAACAAAAG ACTAGTTTTAAGGACAAAGCTACATAAACTCATTGACTTTTTATTAAGGAAAGAAAGTATTATATGCAAG CCAAAGAATGGTCCCACCAGTAGGCAAATGAATTCAAGTCTTCGGCACCGGTCTACCCCAGAACTCTATG GCATATATGTAATTAATGTGCAGTGCCAATTCTGTGAGTATGATGTGTGCATGGAGCCAGCCAAAACTCT GATTGAATTTCAGAACTGGGACACTCTCTTGTTTTGCATTCAGGAAGGAGTGAAAATGTTTTTAAAGCAA GAAAAATTATTTGTGGAATTATCAGGTGAGGATATTAAGGAATTTAGTGAAGATAATGGTTTTAGTTTAT TTGATGCTACTCTTCAGAAGCGTGTGACTTCCGATGAGAGGAGCAATTTCCAGGAAGCATGTAATAATAT TTTAGATTCCTATGAGATGTTTAATTTGCAGTCAAAAGCTGTGAAAAGAAAAACTACTGCAGAAAACGTA AACACACAGAGTTCTAGGGATTCAGAAGCTACCAGAAAAAATACAAATGATGCATTTTTGTACATTTATG AATCAGGTGGTCCAGGCCATAGCAAAATGACAGAGCCATCTTTACAAAACAAAGACAGCTCTTGCTCAGA ATCAAAGATGTTAGAACAAGAGACAATTGTAGCATCAGAAGCTGGAGAAAATGAGAAACATAAAAAATCT TTCCTGGAACATAGCTCTTTAGAAAATCCGTGTGGAACCAGTTTAGAAATGTTTTTAAGCCCTTTTCAGA CACCATGTCACTTTGAGGAGAGTGGGCAGGATCTAGAAATATGGAAAGAAAGTACTACTGTTAATGGCAT GGCTGCCAACATCTTGAAAAATAATAGAATTCAGAATCAACCAAAGAGATTTAAAGATGCTACTGAAGTG GGATGCCAGCCTCTGCCTTTTGCAACAACATTATGGGGAGTACATAGTGCTCAGACAGAGAAAGAGAAAA AAAAAGAATCTAGCAATTGTGGAAGAAGAAATGTTTTTAGTTATGGGCGAGTTAAATTATGTTCCACTGG CTTTATAACTCATGTAGTACAAAATGAAAAAACTAAATCAACTGAAACAGAACATTCATTTAAAAATTAT GTTAGACCTGGTCCCACACGTGCCCAAGAAACATTTGGAAATAGAACACGTCATTCAGTTGAAACTCCAG ACATCAAAGATTTAGCCAGCACTTTAAGTAAAGAATCTGGTCAATTGCCCAACAAAAAAAATTGCAGAAC GAATATAAGTTATGGGCTAGAGAATGAACCTACAGCAACTTATACAATGTTTTCTGCTTTTCAGGAAGGT AGCAAAAAATCACAAACAGATTGCATATTATCTGATACATCCCCCTCTTTCCCCTGGTATAGACACGTTT CCAATGATAGTAGGAAAACAGATAAATTAATTGGTTTCTCCAAACCAATCGTCCGTAAGAAGCTAAGCTT GAGTTCACAGCTAGGATCTTTAGAGAAGTTTAAGAGGCAATATGGGAAGGTTGAAAATCCTCTGGATACA GAAGTAGAGGAAAGTAATGGAGTCACTACCAATCTCAGTCTTCAAGTTGAACCTGACATTCTGCTGAAGG ACAAGAACCGCTTAGAGAACTCTGATGTTTGTAAAATCACTACTATGGAGCATAGTGATTCAGATAGTAG TTGTCAACCAGCAAGCCACATCCTTAACTCAGAGAAGTTTCCATTCTCCAAGGATGAAGATTGTTTAGAA CAACAGATGCCTAGTTTGAGAGAAAGTCCTATGACCCTGAAGGAGTTATCTCTCTTTAATAGAAAACCTT TGGACCTTGAGAAGTCATCTGAATCACTAGCCTCTAAATTATCCAGACTGAAGGGTTCCGAAAGAGAAAC TCAAACAATGGGGATGATGAGTCGTTTTAATGAACTTCCAAATTCAGATTCCAGTAGGAAAGACAGCAAG TTGTGCAGTGTGTTAACACAAGATTTTTGTATGTTATTTAACAACAAGCATGAAAAAACAGAGAATGGTG TCATCCCAACATCAGATTCTGCCACACAGGATAATTCCTTTAATAAAAATAGTAAAACACATTCTAACAG CAATACAACAGAGAACTGTGTGATATCAGAAACTCCTTTGGTATTGCCCTATAATAATTCTAAAGTTACC GGTAAAGATTCAGATGTTCTTATCAGAGCCTCAGAACAACAGATAGGAAGTCTTGACTCTCCCAGTGGAA TGTTAATGAATCCGGTAGAAGATGCCACAGGTGACCAAAATGGAATTTGTTTTCAGAGTGAGGAATCTAA AGCAAGAGCTTGTTCTGAAACTGAAGAGTCAAACACGTGTTGTTCAGATTGGCAGCGGCATTTCGATGTA GCCCTGGGAAGAATGGTTTATGTCAACAAAATGACTGGACTCAGCACATTCATTGCCCCAACTGAGGACA TTCAGGCTGCTTGTACTAAAGACCTGACAACTGTGGCTGTGGATGTTGTACTTGAGAATGGGTCTCAGTA CAGGTGTCAACCTTTTAGAAGCGACCTTGTTCTTCCTTTCCTTCCGAGAGCTCGAGCAGAGAGGACTGTG ATGAGACAGGATAACAGAGATACTGTGGATGATACTGTTAGTAGCGAATCGCTTCAGTCTTTGTTCTCAG AATGGGACAATCCAGTATTTGCCCGTTATCCAGAGGTTGCTGTTGATGTAAGCAGTGGCCAGGCTGAGAG CTTAGCAGTTAAAATTCACAACATCTTGTATCCCTATCGTTTCACCAAAGGAATGATTCATTCAATGCAG GTTCTCCAGCAAGTAGATAACAAGTTTATTGCCTGTTTGATGAGCACTAAGACTGAAGAGAATGGCGAGG CAGGTGGGAACCTGCTCGTGCTGGTGGATCAGCACGCTGCCCATGAGCGTATACGTCTGGAGCAGCTTAT CATTGATTCCTACGAGAAGCAACAGGCACAAGGCTCTGGTCGGAAAAAATTACTGTCTTCTACTCTAATT CCTCCGCTAGAGATAACAGTGACAGAGGAACAAAGGAGACTCTTATGGTGTTACCACAAAAATCTGGAAG ATCTGGGCCTTGAATTTGTATTTCCAGACACTAGTGATTCTCTGGTCCTTGTGGGAAAAGTACCACTATG TTTTGTGGAAAGAGAAGCCAATGAACTTCGGAGAGGAAGATCTACTGTGACCAAGAGTATTGTGGAGGAA TTTATCCGAGAACAACTGGAGCTACTCCAGACCACCGGAGGCATCCAAGGGACATTGCCACTGACTGTCC AGAAGGTGTTGGCATCCCAAGCCTGCCATGGGGCCATTAAGTTTAATGATGGCCTGAGCTTACAGGAAAG TTGCCGCCTTATTGAAGCTCTGTCCTCATGCCAGCTGCCATTCCAGTGTGCTCACGGGAGACCTTCTATG CTGCCGTTAGCTGACATAGACCACTTGGAACAGGAAAAACAGATTAAACCCAACCTCACTAAACTTCGCA AAATGGCCCAGGCCTGGCGTCTCTTTGGAAAAGCAGAGTGTGATACAAGGCAGAGCCTGCAGCAATCCAT GCCTCCCTGTGAGCCACCA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC221591 representing NM_001040108
Red=Cloning site Green=Tags(s) MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETFQVQVIDNGFGMGSDDVEKVG NRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTFVKLFQSGKALKACEADVTRA SAGTTVTVYNLFYQLPVRRKCMDPRLEFEKVRQRIEALSLMHPSISFSLRNDVSGSMVLQLPKTKDVCSR FCQIYGLGKSQKLREISFKYKEFELSGYISSEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKESIICK PKNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQEGVKMFLKQ EKLFVELSGEDIKEFSEDNGFSLFDATLQKRVTSDERSNFQEACNNILDSYEMFNLQSKAVKRKTTAENV NTQSSRDSEATRKNTNDAFLYIYESGGPGHSKMTEPSLQNKDSSCSESKMLEQETIVASEAGENEKHKKS FLEHSSLENPCGTSLEMFLSPFQTPCHFEESGQDLEIWKESTTVNGMAANILKNNRIQNQPKRFKDATEV GCQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGRVKLCSTGFITHVVQNEKTKSTETEHSFKNY VRPGPTRAQETFGNRTRHSVETPDIKDLASTLSKESGQLPNKKNCRTNISYGLENEPTATYTMFSAFQEG SKKSQTDCILSDTSPSFPWYRHVSNDSRKTDKLIGFSKPIVRKKLSLSSQLGSLEKFKRQYGKVENPLDT EVEESNGVTTNLSLQVEPDILLKDKNRLENSDVCKITTMEHSDSDSSCQPASHILNSEKFPFSKDEDCLE QQMPSLRESPMTLKELSLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELPNSDSSRKDSK LCSVLTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTTENCVISETPLVLPYNNSKVT GKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGICFQSEESKARACSETEESNTCCSDWQRHFDV ALGRMVYVNKMTGLSTFIAPTEDIQAACTKDLTTVAVDVVLENGSQYRCQPFRSDLVLPFLPRARAERTV MRQDNRDTVDDTVSSESLQSLFSEWDNPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQ VLQQVDNKFIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLI PPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEE FIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSM LPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAECDTRQSLQQSMPPCEPP TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001040108 |
| ORF Size | 4359 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001040108.2 |
| RefSeq Size | 7911 bp |
| RefSeq ORF | 4362 bp |
| Locus ID | 27030 |
| UniProt ID | Q9UHC1 |
| Protein Families | Druggable Genome |
| Protein Pathways | Mismatch repair |
| MW | 163.5 kDa |
| Gene Summary | This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221591L3 | Lenti-ORF clone of MLH3 (Myc-DDK-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1 |
CNY 16,440.00 |
|
| RC221591L4 | Lenti-ORF clone of MLH3 (mGFP-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1 |
CNY 16,440.00 |
|
| RG221591 | MLH3 (tGFP-tagged) - Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1 |
CNY 15,960.00 |
|
| SC310948 | MLH3 (untagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1 |
CNY 28,030.00 |
