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G protein alpha 13 (GNA13) (NM_006572) Human Untagged Clone
CAT＃: SC116002
GNA13 (untagged)-Human guanine nucleotide binding protein (G protein), alpha 13 (GNA13)
CNY 5,488.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | G13 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC116002 sequence for NM_006572 edited (data generated by NextGen Sequencing)
ATGGCGGACTTCCTGCCGTCGCGGTCCGTGCTGTCCGTGTGCTTCCCCGGCTGCCTGCTG ACGAGTGGCGAGGCCGAGCAGCAACGCAAGTCCAAGGAGATCGACAAATGCCTGTCTCGG GAAAAGACCTATGTGAAGCGGCTGGTGAAGATCCTGCTGCTGGGCGCGGGCGAGAGCGGC AAGTCCACCTTCCTGAAGCAGATGCGGATCATCCACGGGCAGGACTTCGACCAGCNCGCG CGCGAGGAGTTCCGCCCCACCATCTACAGCAACGTGATCAAAGGTATGAGGGTGCTGGTT GATGCTCGAGAGAAGCTTCATATTCCCTGGGGAGACAACTCAAACCAACAACATGGAGAT AAGATGATGTCGTTTGATACCCGGGCCCCCATGGCAGCCCAAGGAATGGTGGAAACAAGG GTTTTCTTACAATATCTTCCTGCTATAAGAGCATTATGGGCAGACAGCGGCATACAGAAT GCCTATGACCGGCGTCGAGAATTTCAACTGGGTGAATCTGTAAAATATTTCCTGGATAAC TTGGATAAACTTGGAGAACCAGATTATATTCCATCACAACAAGATATTCTGCTTGCCAGA AGACCCACCAAAGGCATCCATGAATACGACTTTGAAATAAAAAATGTTCCTTTCAAAATG GTTGATGTAGGTGGTCAGAGATCAGAAAGGAAACGTTGGTTTGAATGTTTCGACAGTGTG ACATCAATACTTTTCCTTGTTTCCTCAAGTGAATTTGACCAGGTGCTTATGGAAGATCGA CTGACCAATCGCCTTACAGAGTCTCTGAACATTTTTGAAACAATCGTCAATAACCGGGTT TTCAGCAATGTCTCCATAATTCTGTTCTTAAACAAGACAGACTTGCTTGAGGAGAAGGTG CAAATTGTGAGCATCAAAGACTATTTCCTAGAATTTGAAGGGGATCCCCACTGCTTAAGA GACGTCCAAAAATTCCTGGTGGAATGTTTCCGGAACAAACGCCGGGACCAGCAACAGAAG CCCTTATACCACCACTTCACCACTGCTATCAACACGGAGAACATCCGCCTTGTTTTCCGT GACGTGAAGGATACTATTCTGCATGACAACCTCAAGCAGCTTATGCTACAGTGA Clone variation with respect to NM_006572.4 236 g=>n >OriGene 5' read for NM_006572 unedited
CGCCCTGCGAGTCAGTTCGCTGGTTCCCTCCCTCCCTGGGCGCGCTCGGGCCGCCGCCGC GCTCCCCGCCCTCGAGCCTCGGTGCCGGAGCCGCCCGCCGCCGGAGGAGGAGGTGGAGGG AGCCGGAGGGGCCCGCCGAGGCGGCGGCGGCGGCGGCAAGATGGCGGACTTCCTGCCGTC GCGGTCCGTGCTGTCCGTGTGCTTCCCCGGCTGCCTGCTGACGAGTGGCGAGGCCGAGCA GCAACGCAAGTCCAAGGAGATCGACAAATGCCTGTCTCGGGAAAAGACCTATGTGAAGCG GCTGGTGAAGATCCTGCTGCTGGGCGCGGGCGAGAGCGGCAAGTCCACCTTCCTGAAGCA GATGCGGATCATCCACGGGCAGGACTTCGACCAGCCGCGCGCGAGGAGTTCCGCCCCACC ATCTACAGCAACGTGATCAAAGGTATGAGGGTGCTGGTTGATGCTCGAGAGAAGCTTCAT ATTCCCTGGGGAGACAACTCAAACCAACAACATGGAGATAAGATGATGTCGTTTGATACC CGGGCCCCCATGGCAGCCCAAGGAATGGTGGAAACAAAGGGTTTTCTTACAATATCTTCC TGCTATAAGAGCATTATGGGCAGACAGCGGCATACAGAATGCCTATGACCCGGCGTCGAG AATTTCAACTGGGTGAATCTGTAAAATATTTNCTGGATAACTTGGGATNAACTTTGGGAG AACCAGATTATNTTNCATCACAACAAGATATTTCTGCTTGNCAAAAGACCCNCCAAAGGC ATNCATGAATACCACTTTTGAATAAAAAATGGTNCTTTCAAATGGGTGTGNGNGNGGGGG GCAAAAATANAAGGNAAACTTTGGTTTTGAATGTTTC >OriGene 3' read for NM_006572 unedited
TTAGCTTGGACCCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGACTTTC TCTAAATTTATTAGGGAGTTTGTTACAAATGTTTGGGCTTTACAGGCATGATTTCACGGA TTCAAACAAGAAATTAACACTGATATTTAGCCTTCTCATGACATACACAGAAATAACATT GCTACAAACTGCAATGGAGAGAATCTTGTTTCAAATGGCTTAGTTTGGGGTTTTGTCTAA ATGTATCATTATATAATGAAAGCACCAATTTGAGGGTTTCTCAAATAGTGATTTGAATTT TAGGACATAACAGTATAACATGGTAACTTTATTCTTCATATATAAATAAGGCATAATCGG ATGTGTATTAATGCTGAAAATACATTTTATCAAAAGCATAAATACAAGTATTTGGGTACA CATTGAAAGTTAGGACTTAACCAATTTCTTCTTACAAAAAATGATAAGGACATATGGTAN TTTGTTGAATCTAAATCAGCACTTCTAATCATTTCTGGTATTAAGGCGATCTTATTTCCT TCTACTTTAAACCAACCACTGCCACCAACTGAATAAGGATTTCCCTAAACAGCCTCAATT TGAGAGACTAACCAGAGGACCTTCTCTATGCAAATTACATGCCAATACACCTTANAAGAA AAATAGACAAAAGTGAATGAGTTTTTTCATTCCATATTGCTTTCTTTGGTTGCAGAGCAA TCCAGTGCCCTTTCCCAGATATAAAATTGAAATGGAAGATTTCAATTTAATATTTTGGCA GACAGCACCAATGCAGGTTATTAAAATATTAAAGGGGCAGAGGCATGCTTTGAATACTCA GATTTCAGAAACATTTGCAAACCCCTTTCTTAAAAGNTATGGCTAAATATAGGTGGTTTA TAGGGACTGAATACATTCCTCAAGCCATGAGCACCTTGGGGGATTCCCTCAAATAATGAA AGCCTCCGATTAGACA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_006572 |
| Insert Size | 5090 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_006572.3, NP_006563.2 |
| RefSeq Size | 4744 bp |
| RefSeq ORF | 1134 bp |
| Locus ID | 10672 |
| UniProt ID | Q14344 |
| Domains | G-alpha |
| Protein Families | Druggable Genome |
| Protein Pathways | Long-term depression, Regulation of actin cytoskeleton, Vascular smooth muscle contraction |
| Gene Summary | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC207762 | GNA13 (Myc-DDK-tagged)-Human guanine nucleotide binding protein (G protein), alpha 13 (GNA13) |
CNY 5,488.00 |
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| RC207762L1 | Lenti-ORF clone of GNA13 (Myc-DDK-tagged)-Human guanine nucleotide binding protein (G protein), alpha 13 (GNA13) |
CNY 7,888.00 |
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| RC207762L2 | Lenti-ORF clone of GNA13 (mGFP-tagged)-Human guanine nucleotide binding protein (G protein), alpha 13 (GNA13) |
CNY 5,890.00 |
|
| RC207762L3 | Lenti-ORF clone of GNA13 (Myc-DDK-tagged)-Human guanine nucleotide binding protein (G protein), alpha 13 (GNA13) |
CNY 5,890.00 |
|
| RC207762L4 | Lenti-ORF clone of GNA13 (mGFP-tagged)-Human guanine nucleotide binding protein (G protein), alpha 13 (GNA13) |
CNY 5,890.00 |
|
| RG207762 | GNA13 (tGFP-tagged) - Human guanine nucleotide binding protein (G protein), alpha 13 (GNA13) |
CNY 7,088.00 |
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