Cytochrome P450 26B (CYP26B1) (NM_001277742) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CYP26A2; P450RAI-2; P450RAI2; RHFCA
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >SC336125 representing NM_001277742. Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGCTCTTTGAGGGCTTGGATCTGGTGTCGGCGCTGGCCACCCTCGCCGCGTGCCTGGTGTCCGTGACG CTGCTGCTGGCCGTGTCGCAGCAGCTGTGGCAGCTGCGCTGGGCCGCCACTCGCGACAAGAGCTGCAAG CTGCCCATCCCCAAGGGATCCATGGGCTTCCCGCTCATCGGAGAGACCGGCCACTGGCTGCTGCAGGTC TTCTCCAAGATCTTCAGCCACGAGGCCCTGGAGAGTTACCTGCCCAAGATCCAGCTGGTGATCCAGGAC ACACTGCGCGCCTGGAGCAGCCACCCCGAGGCCATCAACGTGTACCAGGAGGCGCAGAAGCTGACCTTC CGCATGGCCATCCGGGTGCTGCTGGGCTTCAGCATCCCTGAGGAGGACCTTGGGCACCTCTTTGAGGTC TACCAGCAGTTTGTGGACAATGTCTTCTCCCTGCCTGTCGACCTGCCCTTCAGTGGCTACCGGCGGGGC ATTCAGGCTCGGCAGATCCTGCAGAAGGGGCTGGAGAAGGCCATCCGGGAGAAGCTGCAGTGCACACAG GGCAAGGACTACTTGGACGCCCTGGACCTCCTCATTGAGAGCAGCAAGGAGCACGGGAAGGAGATGACC ATGCAGGAGCTGAAGGACGGGACCCTGGAGCTGATCTTTGCGGCCTATGCCACCACGGCCAGCGCCAGC ACCTCACTCATCATGCAGCTGCTGAAGCACCCCACTGTGCTGGAGAAGCTGCGGGATGAGCTGCGGGCT CATGGCATCCTGCACAGTGGCGGCTGCCCCTGCGAGGGCACACTGCGCCTGGACACGCTCAGTGGGCTG CGCTACCTGGACTGCGTCATCAAGGAGGTCATGCGCCTGTTCACGCCCATTTCCGGCGGCTACCGCACT GTGCTGCAGACCTTCGAGCTTGATGGTTTCCAGATCCCCAAAGGCTGGAGTGTCATGTATAGCATCCGG GACACCCATGACACAGCGCCCGTGTTCAAAGACGTGAACGTGTTCGACCCCGATCGCTTCAGCCAGGCG CGGAGCGAGGACAAGGATGGCCGCTTCCATTACCTCCCGTTCGGTGGCGGTGTCCGGACCTGCCTGGGC AAGCACCTGGCCAAGCTGTTCCTGAAGGTGCTGGCGGTGGAGCTGGCTAGCACCAGCCGCTTTGAGCTG GCCACACGGACCTTCCCCCGCATCACCTTGGTCCCCGTCCTGCACCCCGTGGATGGCCTCAGCGTCAAG TTCTTTGGCCTGGACTCCAACCAGAACGAGATCCTGCCGGAGACGGAGGCCATGCTGAGCGCCACAGTC TAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC
Restriction Sites	SgfI-MluI
ACCN	NM_001277742
Insert Size	1314 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001277742.1
RefSeq Size	4342 bp
RefSeq ORF	1314 bp
Locus ID	56603
UniProt ID	Q9NR63
Protein Families	Druggable Genome, P450
Protein Pathways	Retinol metabolism
MW	49 kDa
Gene Summary	This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013] Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

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