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Prnp (NM_011170) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR227504L3V
- LentiORF®
-
Lenti ORF particles, Prnp (Myc-DDK-tagged) - Mouse prion protein (Prnp), 200ul, >10^7 TU/mL
Mouse Protein / Lysate Request
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Prnp (NM_011170) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AA960666; AI325101; CD230; Prn-i; Prn-p; PrP; prP27-30; prP33-35C; PrP |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_011170 |
| ORF Size | 762 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR227504).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_011170.2 |
| RefSeq Size | 2206 bp |
| RefSeq ORF | 765 bp |
| Locus ID | 19122 |
| Gene Summary | Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (PubMed:12732622, PubMed:16492732, PubMed:19242475, PubMed:19568430).[UniProtKB/Swiss-Prot Function] |
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