TRPM8 (NM_024080) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC220615L1V
- LentiORF®
Lenti ORF particles, TRPM8 (Myc-DDK tagged) - Human transient receptor potential cation channel, subfamily M, member 8 (TRPM8), 200ul, >10^7 TU/mL
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CNY 18,905.00
Cited in 5 publications. |
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CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Product Name | TRPM8 (NM_024080) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | LTrpC-6; LTRPC6; trp-p8; TRPP8 |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_024080 |
ORF Size | 3312 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC220615).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_024080.3 |
RefSeq Size | 5674 bp |
RefSeq ORF | 3315 bp |
Locus ID | 79054 |
Domains | ion_trans |
Protein Families | Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane |
MW | 127.5 kDa |
Gene Summary | Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.[UniProtKB/Swiss-Prot Function] |
Citations (5)
The use of this cDNA Clones has been cited in the following citations: |
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Regeneration of mechanical sciatic nerve injury is affected by cold and heat exposure: involvements of the TRPM2 and TRPM8 channels
,null,
International Journal of Burns and Trauma
,PubMed ID 33500840
[TRPM8]
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Transient Receptor Potential Ion Channel–Dependent Toxicity of Silica Nanoparticles and Poly(amido amine) Dendrimers
,null,
The Journal of Pharmacology and Experimental Therapeutics
,PubMed ID 30442652
[TRPM8]
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Menthol evokes Ca2+ signals and induces oxidative stress independently of the presence of TRPM8 (menthol) receptor in cancer cells
,null,
Redox Biology
,PubMed ID 29078169
[TRPM8]
|
Pilot Study to Determine Whether Transient Receptor Potential Melastatin Type 8 (TRPM8) Antibodies Are Detected in Scleroderma
,null,
Clinical and experimental rheumatology
,PubMed ID 26242276
[TRPM8]
|
Electrophilic Components of Diesel Exhaust Particles (DEP) Activate Transient Receptor Potential Ankyrin-1 (TRPA1): A Probable Mechanism of Acute Pulmonary Toxicity for DEP
,null,
Chemical research in toxicology
,PubMed ID 21591660
[TRPM8]
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