Human Junctional Adhesion Molecule 1 (F11R) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	F11R
Locus ID	50848
Kit Components	GA109467G1, Junctional Adhesion Molecule 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109467G2, Junctional Adhesion Molecule 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109467G3, Junctional Adhesion Molecule 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_016946, NM_144501, NM_144502, NM_144503, NM_144504, NM_001348091
Synonyms	CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1
Summary	Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

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