ITGB3BP (NM_014288) Human Mass Spec Standard

Specifications

Product Data
Description	ITGB3BP MS Standard C13 and N15-labeled recombinant protein (NP_055103)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200064
Predicted MW	20.2 kDa
Protein Sequence	Sequence Link (showhide) >RC200064 protein sequence Red=Cloning site Green=Tags(s) MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHP SLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELENLIGISCASHFLKREMQKTK ELMTKVNKQKLFEKSTGLPHKASRHLDSYEFLKAILN TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_055103
RefSeq Size	1019
RefSeq ORF	531
Synonyms	CENP-R; CENPR; HSU37139; NRIF3; TAP20
Locus ID	23421
Cytogenetics	1p31.3
Summary	This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transcription Factors

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