Adrenomedullin (ADM) (NM_001124) Human Mass Spec Standard

Specifications

Product Data
Description	ADM MS Standard C13 and N15-labeled recombinant protein (NP_001115)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200507
Predicted MW	20.4 kDa
Protein Sequence	Sequence Link (showhide) >RC200507 protein sequence Red=Cloning site Green=Tags(s) MKLVSVALMYLGSLAFLGADTARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVKAGPAQTLIRP QDMKGASRSPEDSSPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSK ISPQGYGRRRRRSLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001115
RefSeq Size	1606
RefSeq ORF	555
Synonyms	AM; PAMP
Locus ID	133
Cytogenetics	11p15.4
Summary	The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
Protein Families	Druggable Genome, Secreted Protein

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