MAN2B1 (NM_000528) Human Mass Spec Standard

CAT#: PH300638

MAN2B1 MS Standard C13 and N15-labeled recombinant protein (NP_000519)



  View other "MAN2B1" proteins (3)

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CNY 14,250.00


货期*
5周

规格
    • 10 ug

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经常一起买 (2)
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MAN2B1 Rabbit polyclonal Antibody
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Specifications

Product Data
Description MAN2B1 MS Standard C13 and N15-labeled recombinant protein (NP_000519)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC200638
Predicted MW 113.7 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000519
RefSeq Size 3231
RefSeq ORF 3033
Synonyms LAMAN; MANB
Locus ID 4125
Cytogenetics 19p13.13
Summary This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Protein Families Druggable Genome
Protein Pathways Lysosome, Other glycan degradation
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