ARH (LDLRAP1) (NM_015627) Human Mass Spec Standard

Specifications

Product Data
Description	LDLRAP1 MS Standard C13 and N15-labeled recombinant protein (NP_056442)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC206643
Predicted MW	33.7 kDa
Protein Sequence	Sequence Link (showhide) >RC206643 representing NM_015627 Red=Cloning site Green=Tags(s) MDALKSAGRALIRSPSLAKQSWGGGGRHRKLPENWTDTRETLLEGMLFSLKYLGMTLVEQPKGEELSAAA IKRIVATAKASGKKLQKVTLKVSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQS LECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSKEEKEKRDKASQEGGDVLGARQDCTPPLKSLVATG NLLDLEETAKAPLSTVSANTTNMDEVPRPQALSGSSVVWELDDGLDEAFSRLAQSRTNPQVLDTGLTAQD MHYAQCLSPVDWDKPDSSGTEQDDLFSF TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_056442
RefSeq Size	2862
RefSeq ORF	924
Synonyms	ARH; ARH1; ARH2; FHCB1; FHCB2; FHCL4
Locus ID	26119
Cytogenetics	1p36.11
Summary	The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome
Protein Pathways	Endocytosis

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