COP (CARD16) (NM_052889) Human Mass Spec Standard

Specifications

Product Data
Description	CARD16 MS Standard C13 and N15-labeled recombinant protein (NP_443121)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC211537
Predicted MW	10.6 kDa
Protein Sequence	Sequence Link (showhide) >RC211537 representing NM_052889 Red=Cloning site Green=Tags(s) MRKAMADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDSVIPKGA QACQICITYICEEDSYLAETLGLSAGPIPGN TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_443121
RefSeq Size	758
RefSeq ORF	303
Synonyms	COP; COP1; PSEUDO-ICE
Locus ID	114769
Cytogenetics	11q22.3
Summary	Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.[UniProtKB/Swiss-Prot Function]

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