CTDSPL (NM_005808) Human Mass Spec Standard

Specifications

Product Data
Description	CTDSPL MS Standard C13 and N15-labeled recombinant protein (NP_005799)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC214440
Predicted MW	29.8 kDa
Protein Sequence	Sequence Link (showhide) >RC214440 representing NM_005808 Red=Cloning site Green=Tags(s) MDGPAIITQVTNPKEDEGRLPGAGEKASQCNVSLKKQRSRSILSSFFCCFRDYNVEAPPPSSPSVLPPLV EENGGLQKPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHV DEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIV DNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDVYSMLHRLCNR TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_005799
RefSeq Size	4422
RefSeq ORF	795
Synonyms	C3orf8; HYA22; PSR1; RBSP3; SCP3
Locus ID	10217
Cytogenetics	3p22.2
Summary	Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.[UniProtKB/Swiss-Prot Function]
Protein Families	Druggable Genome, Phosphatase

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