Adenylate Kinase 1 (AK1) (NM_000476) Human Mass Spec Standard

Specifications

Product Data
Description	AK1 MS Standard C13 and N15-labeled recombinant protein (NP_000467)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC215130
Predicted MW	21.5 kDa
Protein Sequence	Sequence Link (showhide) >RC215130 representing NM_000476 Red=Cloning site Green=Tags(s) MEEKLKKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLE TVLDMLRDAMVAKVNTSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVD DNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHLDALK TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000467
RefSeq Size	2271
RefSeq ORF	582
Synonyms	HTL-S-58j
Locus ID	203
Cytogenetics	9q34.11
Summary	This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Purine metabolism

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