Cytochrome P450 2A6 (CYP2A6) (NM_000762) Human Mass Spec Standard

CAT#: PH322995

CYP2A6 MS Standard C13 and N15-labeled recombinant protein (NP_000753)



  View other "Cytochrome P450 2A6" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of cytochrome P450, family 2, subfamily A, polypeptide 6 (CYP2A6)
    • 100 ug

CNY 4,840.00


CYP2A6 (Cytochrome P450 2A6) mouse monoclonal antibody, clone OTI1D2 (formerly 1D2)
    • 100 ul

CNY 1,999.00
CNY 2,700.00

Specifications

Product Data
Description CYP2A6 MS Standard C13 and N15-labeled recombinant protein (NP_000753)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC222995
Predicted MW 56.5 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000753
RefSeq Size 1775
RefSeq ORF 1482
Synonyms CPA6; CYP2A; CYP2A3; CYPIIA6; P450C2A; P450PB
Locus ID 1548
Cytogenetics 19q13.2
Summary This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, P450, Transmembrane
Protein Pathways Caffeine metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Retinol metabolism
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