INCA (CARD17) (NM_001007232) Human Mass Spec Standard

Specifications

Product Data
Description	CARD17 MS Standard C13 and N15-labeled recombinant protein (NP_001007233)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC224934
Predicted MW	11.7 kDa
Protein Sequence	Sequence Link (showhide) >RC224934 representing NM_001007232 Red=Cloning site Green=Tags(s) MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDSVIRKGAPACQ ICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001007233
RefSeq Size	466
RefSeq ORF	330
Synonyms	INCA
Locus ID	440068
Cytogenetics	11q22.3
Summary	Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.[UniProtKB/Swiss-Prot Function]

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