Geldanamycin Protein

Specifications

Product Data
Predicted MW	1034.2
Purity	>98% 98 % (TLC: 10 % Methanol.methylene chloride; Rf=0.31)
Conjugation	FITC
Buffer	State: Purple solid - FITC Presentation Label: FITC
Preparation	Purple solid - FITC
Protein Description	Formula: C55H63N5O13S
Storage	Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C. Avoid repeated freezing and thawing. Protect from light.
Stability	Shelf life: One year from despatch.
Reference Data
Summary	Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1α (3). This is specifically a novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for Hsp90 inhibitors (4). May also be used for detection of cell surface Hsp90 (5). Other geldanamycin fluorophores (BODPY) have been reported and used in FP HTS assays (6,7)

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