RAIDD (1-199, His-tag) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MGSSHHHHHH SSGLVPRGSH MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEINAQTTG LRKTMLMLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPMVLSLGL SQTDIYRCKA NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE
Tag	His-tag
Predicted MW	24.9 kDa
Concentration	lot specific
Purity	>95% >/= 95% by SDS PAGE
Buffer	Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM TRIS pH 8.0, 20% glycerol
Preparation	Liquid purified protein
Protein Description	Recombinant CRADD protein, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques.
Note	NCBI Accession No.: NP_003796
Storage	Store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_001307028
Locus ID	8738
UniProt ID	P78560, Q53XL1, Q8IY43
Cytogenetics	12q22
Synonyms	MRT34; RAIDD
Summary	This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Protein Families	Druggable Genome

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