DCUN1D1 (NM_020640) Human Recombinant Protein

CAT#: TP720243M

Recombinant protein of human DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) (DCUN1D1)

Size: 10 ug 50 ug 500 ug 1 mg



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CNY 7,220.00


货期*
2周

规格
    • 50 ug

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经常一起买 (1)
Goat Anti-DCUN1D1 Antibody
    • 100 ug

CNY 5,371.00

Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Tag N-His
Predicted MW 32.3 kDa
Concentration lot specific
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Supplied as a 0.2 um filtered solution of PBS, pH 7.4.
Storage Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Endotoxin < 0.1 EU per µg protein as determined by LAL test
Reference Data
RefSeq NP_065691
Locus ID 54165
UniProt ID Q96GG9, B4DM76
Cytogenetics 3q26.33
Synonyms DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3
Summary Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).[UniProtKB/Swiss-Prot Function]
Protein Families Druggable Genome
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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