AXL Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) A26-P449
Tag	C-8His
Buffer	Supplied as a 0.2 um filtered solution of PBS, pH7.2
Note	Recombinant Human Tyrosine-protein Kinase Receptor UFO is produced by Human 293 Cells. The target gene encoding A26-P449 is expressed with a 8His tag at the C terminus.
Storage	Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Stability	12 months from date of despatch
Reference Data
Locus ID	558
UniProt ID	P30530
Summary	Tyrosine-protein kinase receptor UFO, also known as AXL receptor tyrosine kinase, is a member of protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL is highly expressed in metastatic colon tumors, while only weakly expressed in normal colon tissue. AXL functions in dampening the immune response, mediating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. It is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. AXL also plays a role in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thereby implicated in the stimulation of cell proliferation.

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