IGFBP7 Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Ser27-Leu282
Tag	C-6His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, 0.05%Tween 80, pH7.4
Note	Recombinant Human Insulin-like Growth Factor-binding Protein 7 is produced by our Mammalian expression system and the target gene encoding Ser27-Leu282 is expressed with a 6His tag at the C-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	3490
UniProt ID	Q16270
Summary	Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that is a member of the insulin-like growth factor (IGF) binding proteins superfamily. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. IGFBP7 is expressed in multiple normal tissues as well as cancer cells. It is highly expressed in high endothelial venules (HEVs) of blood vessels in the secondary lymphoid tissues. IGFBP7 interacts with heparan sulfate proteoglycans, type IV collagen, and specific chemokines. It supports weak cell adhesion, facilitates cell spreading on type IV collagen, and stimulates the production of the potent vasodilator PGI2. In addition, IGFBP7 modulates tumor cell growth and has also been implicated in angiogenesis.

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