DHLAG (CD74) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Gln73-Met232
Tag	N-6His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant Human CD74 is produced by Human Cells. The target gene encoding Gln73-Met232 is expressed with a N-His tag.
Stability	12 months from date of despatch
Reference Data
Locus ID	972
UniProt ID	P04233
Summary	Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.

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