STING (TMEM173) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Val155-Val341
Tag	N-His&SUMO
Buffer	Supplied as a 0.2 um filtered solution of PBS, pH 7.4.
Note	Recombinant Human Stimulator of Interferon Genes Protein is produced by our E.coli expression system and the target gene encoding Val155-Val341 is expressed with a 6His, Sumo tag at the N-terminus.
Stability	12 months from date of despatch
Reference Data
Locus ID	340061
UniProt ID	Q86WV6
Summary	Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). It ubiquitously expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophagesand. Its subunit structure associated with the MHC-II complex and Interacts with DDX58/RIG-I, MAVS and SSR2, RNF5 and TRIM56 along with TBK1. This type of protein often uses as facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon.

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