Mutant ORF Clones

cDNA Clones

Mutant ORF Clones

Human

MLH1

MSH2

P53

MSH6

PI 3 KINASE CATALYTIC SUBUNIT ALPHA

EGFR

BRAF

CTNNB1

KRAS

RAF1

BETA CATENIN

B RAF

MET

MAP2K1

AXIN1

AXIN2

MEK1

AKT1

MYC

BCL2

PIK3CA

Myc-DDK

pCMV6-Entry

pCMV6-AC-Myc-DDK

pCMV6-AN-Myc-DDK

Yes

TrueORF

Druggable Genome

Stem cell - Pluripotency

Transcription Factors

Protein Kinase

ES Cell Differentiation/IPS

Transmembrane

Stem cell relevant signaling - JAK/STAT signaling pathway

Adult stem cells

Cancer stem cells

Secreted Protein

Stem cell relevant signaling - Wnt Signaling pathway

Induced pluripotent stem cells

Embryonic stem cells

Stem cell relevant signaling - TGFb/BMP signaling pathway

Pathways in cancer

Colorectal cancer

Insulin signaling pathway

Endometrial cancer

Pancreatic cancer

Mismatch repair

Prostate cancer

Melanoma

Thyroid cancer

Glioma

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

mTOR signaling pathway

p53 signaling pathway

Non-small cell lung cancer

Ubiquitin mediated proteolysis

Chronic myeloid leukemia

MAPK signaling pathway

Focal adhesion

Bladder cancer

Neurotrophin signaling pathway

Metabolic pathways

Type II diabetes mellitus

ErbB signaling pathway

Regulation of actin cytoskeleton

Endocytosis

Primary immunodeficiency

Renal cell carcinoma

Homologous recombination

Small cell lung cancer

Amino sugar and nucleotide sugar metabolism

Galactose metabolism

Glycolysis / Gluconeogenesis

Maturity onset diabetes of the young

Starch and sucrose metabolism

Natural killer cell mediated cytotoxicity

Dorso-ventral axis formation

Chemokine signaling pathway

Acute myeloid leukemia

Melanogenesis

Long-term depression

T cell receptor signaling pathway

Gap junction

Wnt signaling pathway

Apoptosis

VEGF signaling pathway

GnRH signaling pathway

Cell cycle

Tight junction

Basal cell carcinoma

Long-term potentiation

Progesterone-mediated oocyte maturation

Notch signaling pathway

Adherens junction

Vascular smooth muscle contraction

Leukocyte transendothelial migration

Phosphatidylinositol signaling system

Amyotrophic lateral sclerosis (ALS)

Huntington's disease

Fc gamma R-mediated phagocytosis

Jak-STAT signaling pathway

Inositol phosphate metabolism

Calcium signaling pathway

Cytokine-cytokine receptor interaction

Toll-like receptor signaling pathway

Adipocytokine signaling pathway

Axon guidance

Citrate cycle (TCA cycle)

Vibrio cholerae infection

Pathogenic Escherichia coli infection

Epithelial cell signaling in Helicobacter pylori infection

Dilated cardiomyopathy

Taste transduction

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Nucleotide excision repair

Prion diseases

TGF-beta signaling pathway

Oocyte meiosis

Cell adhesion molecules (CAMs)

Glutathione metabolism

Neuroactive ligand-receptor interaction

Base excision repair

Metabolism of xenobiotics by cytochrome P450

Complement and coagulation cascades

Hematopoietic cell lineage

PPAR signaling pathway

Neomycin

None

1

Yes

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