活动过滤器
优化搜索结果
Target Symbol
- BRCA1 (432)
- BTK (325)
- GLUCOKINASE (296)
- MENIN (296)
- BRCA2 (288)
- MLH1 (287)
- TUBERIN (264)
- MSH2 (240)
- IFNG (230)
- P53 (227)
- RET (213)
- FGFR1 (177)
- PDE9A (176)
- NOTCH3 (172)
- BDNF (167)
- DISC1 (165)
- VEGFA (161)
- CREM (159)
- NF2 (159)
- ALPHA 1 ANTITRYPSIN (150)
- NRG1 (150)
- CONSTITUTIVE ANDROSTANE RECEPTOR (139)
- NDRG2 (133)
- MORTALITY FACTOR 4 LIKE 2 (131)
- BIN1 (126)
- G PROTEIN ALPHA S (120)
- WILMS TUMOR PROTEIN (119)
- CTNND1 (117)
- UBE2D3 (117)
- IL10 (115)
- DYSTROBREVIN ALPHA (114)
- EMA (113)
- IRF5 (113)
- MU OPIOID RECEPTOR (113)
- DYSTROPHIN (109)
- MSH6 (109)
- RIBONUCLEASE INHIBITOR (107)
- ST3GAL3 (107)
- CACNA1G (106)
- EGFR (106)
- NCALD (105)
- LKB1 (104)
- PLAGL1 (104)
- TGIF (103)
- IL32 (102)
- BETA CATENIN (101)
- HMGA1 (101)
- MYOSIN (101)
- TPM1 (101)
- FHL1 (100)
- PQBP1 (100)
- SSH3BP1 (99)
- SYNTABULIN (99)
- ASPARTATE BETA HYDROXYLASE (98)
- SYTL2 (98)
- ALKALINE PHOSPHATASE (96)
- APC11 (96)
- CD46 (96)
- FGF1 (94)
- HNF 4 ALPHA (94)
- OSBPL9 (94)
- PCBP2 (94)
- NAT1 (93)
- PML PROTEIN (93)
- UBE2V1 (93)
- MEIS2 (92)
- MTH1 (92)
- RUNX1T1 (92)
- TCF7L2 (91)
- ATAXIN 3 (90)
- HFE (90)
- UTY (90)
- FGFR2 (89)
- CAMK2B (88)
- IKZF3 (88)
- MBNL1 (88)
- RGS3 (88)
- AURORA A (87)
- CD1E (87)
- GM CSF RECEPTOR ALPHA (87)
- P38 (87)
- GPR56 (86)
- HNRNP F (86)
- IKAROS (86)
- MAX (86)
- PRKAR1B (86)
- CD59 (85)
- ESTROGEN RELATED RECEPTOR GAMMA (85)
- PPP2R2B (85)
- AMYLOID PRECURSOR PROTEIN (84)
- CPNE1 (84)
- FH (84)
- RAD17 (84)
- TAU (84)
- ZFYVE27 (84)
- CACNA1C (83)
- CAMKK2 (83)
- CHRM2 (83)
- GLUCOCORTICOID RECEPTOR (83)
- NEK6 (83)
Reactivities
Applications
Expression Hosts
Lentivirus
Tags
- Myc-DDK (82032)
- C-Myc/DDK (77343)
- Tag Free (44785)
- TurboGFP (38910)
- mGFP (38899)
- C-MYC/DDK (19716)
- N-His (2056)
- N-GST and C-His (441)
- C-DDK (195)
- C-His (180)
- N-GST and C-HIS (150)
- C-6His (106)
- C-DDK/His (102)
- DDK-His (76)
- His-tag (66)
- N-His-ABP (Albumin-Binding Protein) (52)
- C-HIS (45)
- C-Human Fc (44)
- C-Mouse Fc and 6×His (30)
- His-Tag (30)
- C-Fc (28)
- C-8His (22)
- C-Mouse Fc (21)
- N-His-Trx (18)
- C-hFc (16)
- C-6×His (15)
- N-6His (15)
- C-Human Fc and 6×His (14)
- N-GST, C-His (13)
- C-Avi&6His (7)
- Tag-free (7)
- C- 6×His (6)
- N-GST (6)
- hIgG-Tag (6)
- C-10His (5)
- N-HIS (5)
- N-His PDCD1(Pro21-Val170) (5)
- N-Mouse Fc and C-6×His (5)
- N-Avi (4)
- N-His&C-His (4)
- N-His-GST (4)
- N-His/DDK (4)
- C-Fc/His (3)
- C-hFc&His (3)
- N-8His (3)
- hIgG-His-Tag (3)
- C-HUMAN (2)
- C-Myc-DDK (2)
- N-DDK (2)
- N-His-PDCD1(Pro21-Val170) (2)
- N-Human Fc (2)
- N-terminal His (2)
- N-terminal His-PDCD1(Pro21-Val170) tag (2)
- C-6xHis/AVI (1)
- C-AVI-PLUS (1)
- C-Avi-His (1)
- C-DDK-His (1)
- C-DDK/10xHis (1)
- C-DDK/6xHis (1)
- C-FC (1)
- C-HIS/C (1)
- C-HIS/DDK (1)
- C-His/DDK (1)
- C-Human Fc, Avi (1)
- C-Human Fc-Avi (1)
- C-hIgG1 Fc (1)
- C-hIgG4P Fc (1)
- C-mFc (1)
- C-terminal DDK (1)
- C-terminal His (1)
- N-6His-FLAG (1)
- N-8His&N-FLAG (1)
- N-AVI (1)
- N-Avi&6His (1)
- N-DDK/His (1)
- N-FLAG (1)
- N-FUSION (1)
- N-Fc-FLAG (1)
- N-Flag&C-His (1)
- N-GFP (1)
- N-GST(CKM) and N-His(CKB) (1)
- N-GST/C-His (1)
- N-Mouse Fc (1)
- N-T7 (1)
- N-TRX (1)
- N-TRXA (1)
- N-Trx-His (1)
- N-hFc (1)
- No (1)
- Tag free (1)
Vectors
- pCMV6-Entry (61012)
- pCMV6-AC-GFP (38954)
- pLenti-C-Myc-DDK-P2A-Puro (28680)
- pLenti-C-mGFP-P2A-Puro (28611)
- pRS (20309)
- pGFP-C-shLenti (20254)
- EF1a-GFP-P2A-Puro (19104)
- pCMV6-XL5 (11549)
- pLenti-C-Myc-DDK (10559)
- pLenti-C-mGFP (10289)
- pCMV6-XL4 (5167)
- pCMV6-AC (3791)
- pCMVMIR (1829)
- pGFP-V-RS (1369)
- RFP-BSD (1103)
- Luciferase-Puro (1102)
- mBFP-Neo (1102)
- GFP-puro (1101)
- pRFP-C-RS (932)
- pCMV6-XL6 (791)
- PCMV6-Neo (247)
- pCMV6-AC-Myc-DDK (132)
- pCMV6-XL5-DDK-His (76)
- pCMV6-AN-Myc-DDK (27)
- pRMT-tGFP, Promoter-less GFP Reporter Vector (3)
- pCMV6-Entry2 (1)
Reporters
Conjugates
Mutants
Assay Types
Brands
QC Levels
Families
- Druggable Genome (110598)
- Transmembrane (63647)
- WB (40474)
- Transcription Factors (28961)
- Secreted Protein (18113)
- Protein Kinase (10393)
- Protease (6587)
- ES Cell Differentiation/IPS (6235)
- Stem cell - Pluripotency (5648)
- GPCR (3802)
- Phosphatase (2910)
- Ion Channels: Other (1982)
- Adult stem cells (1438)
- Nuclear Hormone Receptor (1321)
- Embryonic stem cells (1174)
- Ion Channels: Potassium (966)
- Cancer stem cells (711)
- P450 (699)
- Induced pluripotent stem cells (651)
- Ion Channels: Cys-loop Receptors (569)
- Stem cell relevant signaling - JAK/STAT signaling pathway (461)
- Ion Channels: Transient receptor potential (380)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (364)
- Stem cell relevant signaling - Wnt Signaling pathway (284)
- Ion Channels: Glutamate Receptors (277)
- Stem cell relevant signaling - DSL/Notch pathway (275)
- Ion Channels: Calcium (229)
- Ion Channels: Sodium (156)
- Ion Channels: ATP Receptors (137)
- Ion Channels: Cyclic nucleotide gated (81)
- ELISA (49)
- SDS-PAGE (33)
- Bioactivity (24)
- 10 mM Tris-HCl (12)
- the solution can be further dialyzed against PBS (phosphate buffered saline (12)
- Flow Cyt (11)
- 2 mM dithiothreitol (10)
-
ELISA.
Western Blot. (10) - e.g. Dulbecco's PBS). (10)
- Enzyme Activity (9)
- both dissolved in 9.5 M urea buffer (see above). Protofilaments and filament complexes are obtained by dialyzing the resulting polypeptide solution stepwise to a concentration of 4 M urea and then to low salt condition (50 mM NaCl (8)
-
Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoassays.
Immunization.
Protocol: Reconstitution to filaments is performed by mixing equimolar amounts of keratins of type I and type II at concentrations of approx. 0.5 mg/ml (6) - pH 7.4). For immunization purposes (6)
-
Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoassays.
Immunization.
Protocol: Reconstitution to filaments is performed by mixing equimolar amounts of keratins of type I and type II at concentrations of approx. 0.5 mg/ml (4) -
pH 7.4).
For immunization purposes (4) -
pH 7.4).
For immunization purposes (4) - Western Blot. (3)
- 0.1% (w/v) insulin (2)
- 10mM Tris-HCl (2)
- 1mM DTT (2)
- 2 mM dithiothreitol (2)
-
2mM EDTA.
2. Add 4ug of recombinant thioredoxin into reaction cocktail and mix immediately.
3. Incubate at 25°C for 20 minutes.
4. Record the increase in A650nm for 15 minutes (2) - 2mM dithiothreitol (2)
- 63mM sodium phosphate (2)
-
Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoassays.
Immunization.
Protocol: Reconstitution to filaments: After vimentin is dissolved in 9.5M Urea buffer (see above) (2) - Can be used as standard in a Sandwich ELISA. (2)
- FACS (2)
-
Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoassays.
Immunization.
Protocol: Reconstitution to filaments: after desmin is dissolved in 9.5 M urea buffer (see above) (2) -
Protocol: Activity Assay
1. Prepare a 1 ml reaction cocktail into a suitable container: The final concentrations are 5mM Tris (2) - Secreted (2)
-
both dissolved in 9.5 M urea buffer (see above).
Protofilaments and filament complexes are obtained by dialyzing the resulting polypeptide solution stepwise to a concentration of 4 M urea and then to low salt condition (50 mM NaCl (2) - e.g. Dulbeccos PBS). (2)
- e.g.Dulbecco's PBS). (2)
- protofilaments and filament complexes are obtained by dialyzing the resulting polypeptide solution stepwise to a concentration of 4M Urea and then to low salt condition (50mM NaCl (2)
- protofilaments and filament complexes are obtained by dialyzing the resulting polypeptide solution stepwise to a concentration of 4M urea and then to low salt condition (50 mM NaCl (2)
- the solution can be further dialyzed against PBS (Phosphate Buffered Saline (2)
-
ELISA.
Suitable for use as a Control or standard in indirect trapping ELISA for quantitation of antigen in serum using a standard curve.
Immunoprecipitation.
Western blotting. (1) -
ELISA.
Western Blot. (1) -
ELISA.
Western blotting. (1) - ELISA. (1)
- Positive control for Western blot analysis (1)
-
Positive control for Western blot analysis.
Standard for ELISA. (1) -
Adermann K. Role of the prosequence of guanylin. Protein Sci. 1999 Sep; 8(9): 1850-9.
4. Lauber T (1) -
Cell culture and/or animal studies.
ELISA.
Western Blot. (1) -
Cohen MB. Proguanylin secretion and the role of negative-feedback inhibition in a villous epithelial cell line. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3): G695-702.
3. Schulz A (1) - For use as a Control or Standard in Indirect trapping ELISA for quantitation of antigen in serum using a standard curve (1)
-
For use as a Control or standard in indirect trapping ELISA for quantitation of antigen in serum using a standard curve.
Immunoprecipitation.
Western blotting. (1) - Forssmann WG (1)
- Hawkins JA (1)
- Hidaka Y (1)
- Marx UC (1)
-
Marx UC. Native and recombinant proguanylin feature identical biophysical properties and are monomeric in solution. Biochemistry. 2002 Dec 10; 41(49): 14602-12.
2. Rudolph JA (1) - Marx UC. Solution structure of human proguanylin: the role of a hormone prosequence. J Biol Chem. 2003 Jun 27; 278(26): 24118-24. Epub 2003 Apr 21. (1)
- Neudecker P (1)
- Nourse A (1)
- Rosch P (1)
- Schulz A (1)
- Shimonishi Y (1)
- Specific methodologies have not been tested using this product. (1)
-
Western Blot.
Protocol: 1. Lauber T (1) - Western Blotting. (1)
- for immunoprecipitation and for Wwestern blotting. (1)
Pathways
- Metabolic pathways (19600)
- Pathways in cancer (9327)
- MAPK signaling pathway (6668)
- Cytokine-cytokine receptor interaction (5037)
- Regulation of actin cytoskeleton (4778)
- Focal adhesion (4502)
- Neuroactive ligand-receptor interaction (4194)
- Endocytosis (4121)
- Chemokine signaling pathway (3839)
- Neurotrophin signaling pathway (3586)
- Insulin signaling pathway (3526)
- Calcium signaling pathway (3453)
- Ubiquitin mediated proteolysis (3382)
- Wnt signaling pathway (3363)
- Huntington's disease (3124)
- Purine metabolism (3115)
- Jak-STAT signaling pathway (3009)
- Alzheimer's disease (3006)
- Natural killer cell mediated cytotoxicity (2960)
- Colorectal cancer (2868)
- Olfactory transduction (2820)
- Axon guidance (2805)
- Tight junction (2793)
- Cell cycle (2755)
- Progesterone-mediated oocyte maturation (2751)
- Prostate cancer (2714)
- T cell receptor signaling pathway (2681)
- Leukocyte transendothelial migration (2679)
- ErbB signaling pathway (2578)
- Pancreatic cancer (2558)
- Cell adhesion molecules (CAMs) (2472)
- Oocyte meiosis (2437)
- Toll-like receptor signaling pathway (2339)
- Apoptosis (2335)
- GnRH signaling pathway (2323)
- Melanoma (2272)
- Adherens junction (2241)
- Vascular smooth muscle contraction (2226)
- Lysosome (2219)
- Melanogenesis (2204)
- B cell receptor signaling pathway (2190)
- Fc gamma R-mediated phagocytosis (2166)
- Fc epsilon RI signaling pathway (2110)
- Chronic myeloid leukemia (2106)
- Endometrial cancer (2087)
- Hematopoietic cell lineage (2079)
- p53 signaling pathway (2056)
- Dilated cardiomyopathy (2042)
- Small cell lung cancer (2038)
- Glioma (2010)
- VEGF signaling pathway (1991)
- Renal cell carcinoma (1950)
- Spliceosome (1950)
- Gap junction (1926)
- Hypertrophic cardiomyopathy (HCM) (1877)
- Parkinson's disease (1846)
- Systemic lupus erythematosus (1793)
- Pyrimidine metabolism (1773)
- Oxidative phosphorylation (1746)
- Non-small cell lung cancer (1743)
- Acute myeloid leukemia (1730)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (1720)
- Long-term potentiation (1703)
- TGF-beta signaling pathway (1642)
- mTOR signaling pathway (1642)
- Long-term depression (1634)
- Adipocytokine signaling pathway (1619)
- Glycolysis / Gluconeogenesis (1565)
- PPAR signaling pathway (1546)
- Antigen processing and presentation (1523)
- Phosphatidylinositol signaling system (1504)
- Bladder cancer (1492)
- NOD-like receptor signaling pathway (1477)
- RIG-I-like receptor signaling pathway (1463)
- Type II diabetes mellitus (1451)
- Epithelial cell signaling in Helicobacter pylori infection (1435)
- Viral myocarditis (1432)
- Thyroid cancer (1410)
- Amyotrophic lateral sclerosis (ALS) (1370)
- Complement and coagulation cascades (1370)
- ECM-receptor interaction (1322)
- Cardiac muscle contraction (1294)
- Pathogenic Escherichia coli infection (1272)
- Ribosome (1237)
- Glycerophospholipid metabolism (1233)
- Drug metabolism - cytochrome P450 (1188)
- Metabolism of xenobiotics by cytochrome P450 (1165)
- Amino sugar and nucleotide sugar metabolism (1146)
- Basal cell carcinoma (1135)
- Vibrio cholerae infection (1133)
- Cytosolic DNA-sensing pathway (1118)
- Starch and sucrose metabolism (1114)
- Inositol phosphate metabolism (1112)
- Arginine and proline metabolism (1072)
- Primary immunodeficiency (1004)
- Mismatch repair (972)
- Valine (968)
- Retinol metabolism (964)
- Hedgehog signaling pathway (962)
- Drug metabolism - other enzymes (943)
- Glutathione metabolism (939)
- RNA degradation (937)
- Notch signaling pathway (895)
- Arachidonic acid metabolism (888)
- Tyrosine metabolism (841)
- Autoimmune thyroid disease (830)
- leucine and isoleucine degradation (828)
- Pyruvate metabolism (809)
- Nucleotide excision repair (807)
- Fatty acid metabolism (798)
- Proteasome (794)
- Glycerolipid metabolism (792)
- Galactose metabolism (779)
- Type I diabetes mellitus (768)
- Homologous recombination (750)
- Lysine degradation (750)
- Taste transduction (748)
- Maturity onset diabetes of the young (738)
- Tryptophan metabolism (734)
- Sphingolipid metabolism (730)
- Prion diseases (722)
- Cysteine and methionine metabolism (709)
- Base excision repair (693)
- N-Glycan biosynthesis (693)
- Dorso-ventral axis formation (690)
- Citrate cycle (TCA cycle) (681)
- Fructose and mannose metabolism (678)
- Graft-versus-host disease (674)
- Alanine (666)
- aspartate and glutamate metabolism (666)
- Androgen and estrogen metabolism (633)
- Porphyrin and chlorophyll metabolism (623)
- Allograft rejection (616)
- SNARE interactions in vesicular transport (613)
- DNA replication (586)
- Propanoate metabolism (586)
- Butanoate metabolism (577)
- Aminoacyl-tRNA biosynthesis (575)
- Ether lipid metabolism (562)
- Pentose phosphate pathway (552)
- Regulation of autophagy (548)
- Histidine metabolism (541)
- ABC transporters (535)
- Glycine (528)
- serine and threonine metabolism (528)
- Glycosphingolipid biosynthesis - lacto and neolacto series (521)
- Nitrogen metabolism (517)
- Selenoamino acid metabolism (496)
- Basal transcription factors (467)
- Linoleic acid metabolism (450)
- RNA polymerase (438)
- Glycosaminoglycan degradation (430)
- Phenylalanine metabolism (420)
- Asthma (419)
- Nicotinate and nicotinamide metabolism (419)
- O-Glycan biosynthesis (416)
- beta-Alanine metabolism (408)
- Pentose and glucuronate interconversions (380)
- Glycosylphosphatidylinositol(GPI)-anchor biosynthesis (348)
- Pantothenate and CoA biosynthesis (345)
- Ascorbate and aldarate metabolism (341)
- Riboflavin metabolism (334)
- One carbon pool by folate (331)
- Primary bile acid biosynthesis (328)
- Biosynthesis of unsaturated fatty acids (326)
- Sulfur metabolism (319)
- Heparan sulfate biosynthesis (318)
- Other glycan degradation (318)
- Renin-angiotensin system (307)
- Keratan sulfate biosynthesis (303)
- alpha-Linolenic acid metabolism (290)
- Glyoxylate and dicarboxylate metabolism (284)
- Terpenoid backbone biosynthesis (284)
- Steroid biosynthesis (281)
- Glycosphingolipid biosynthesis - globo series (267)
- Chondroitin sulfate biosynthesis (261)
- Non-homologous end-joining (254)
- Limonene and pinene degradation (237)
- Circadian rhythm - mammal (234)
- Glycosphingolipid biosynthesis - ganglio series (234)
- leucine and isoleucine biosynthesis (212)
- C21-Steroid hormone metabolism (211)
- Taurine and hypotaurine metabolism (206)
- Folate biosynthesis (201)
- Cyanoamino acid metabolism (183)
- Thiamine metabolism (176)
- Protein export (173)
- Caffeine metabolism (155)
- Synthesis and degradation of ketone bodies (146)
- Fatty acid elongation in mitochondria (137)
- Methane metabolism (122)
- Ubiquinone and other terpenoid-quinone biosynthesis (107)
- Fatty acid biosynthesis (95)
- Phenylalanine (78)
- tyrosine and tryptophan biosynthesis (78)
- Lysine biosynthesis (77)
- Lipoic acid metabolism (70)
- Vitamin B6 metabolism (69)
- D-Glutamine and D-glutamate metabolism (65)
- O-Mannosyl glycan biosynthesis (56)
- Biotin metabolism (44)
- D-Arginine and D-ornithine metabolism (11)