Caspase 5 (CASP5) Rabbit Polyclonal Antibody

CAT#: AP05927PU-N

Caspase 5 (CASP5) rabbit polyclonal antibody, Purified



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CNY 5,694.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Applications IF, WB
Recommend Dilution Western blot: 1.0 µg/ml - 2.0 µg/ml; detects a band of approximately 48 kDa in Ramos cell lysates. (Predicted precursor MWT 47.8kDa).
Immuncytochemistry.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen A 14 amino acid peptide from the centre of human Caspase-5.
Specificity This antibody recognises an epitope located within the internal region of human Caspase-5, a 47kDa cysteine protease, otherwise known as ICH-3.
Formulation Phosphate buffered saline containing 0.02% Sodium Azide
State: Purified
State: Liquid purified Ig
Concentration lot specific
Purification Affinity chromatography
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name caspase 5
Background Caspase-5 has been shown to be expressed at higher levels in the colon, lung, spleen, small intestine and by peripheral blood lymphocytes.
Caspase-5 is a member of a growing number of inflammatory caspases belonging to the Caspase-1 (ICE-type) subfamily, which require proteolytic processing of their inactive precursor into smaller active subunits. Unlike Caspase-1, Caspase-5 is not directly responsible for the activation of IL-1Beta from the pro-IL-1Beta precursor, but the presence of Caspase-5 does appear to enhance the processing of IL-1Beta.
The in vivo expression of Caspase-5 is elevated by Lipopolysaccharide (LPS) and gene expression is also increased by Interferon gamma (IFNg). In vitro studies have shown cleavage of Caspase-5 by the serine protease Granzyme B, which plays a major role in Cytotoxic T lymphocyte (CTL)-induced apoptosis (1).
Synonyms CASP-5, CASP5, ICH3, ICH-3 protease, TY protease, ICE(rel)-III
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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