c Fos (FOS) pThr232 Rabbit Polyclonal Antibody

CAT#: AP55783PU-S

c Fos (FOS) pThr232 rabbit polyclonal antibody, Aff - Purified

Size: 50 ul 100 ul



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CNY 1,400.00


货期*
2周

规格
    • 50 ul

Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution Western blot: 1:500~1:1000.
Immunohistochemistry on paraffin sections: 1:50~1:100.
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Peptide sequence around phosphorylation site of threonine 232(V-A-T(p)-P-E) derived from Human FOS (KLH-conjugated)
Specificity The antibody detects endogenous levels of FOS only when phosphorylated at threonine 232.
Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
State: Aff - Purified
State: Liquid Ig fraction
Concentration lot specific
Purification Affinity chromatography using epitope-specific peptide
Conjugation Unconjugated
Storage Condition Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Predicted Protein Size 48 kDa
Gene Name Fos proto-oncogene, AP-1 transcription factor subunit
Background Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Synonyms FOS, G0S7
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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