ROCK1 (NM_005406) Human 3' UTR Clone

Specifications

Product Data
Product Name	ROCK1 (NM_005406) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	P160ROCK; ROCK-I
ACCN	NM_005406
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC215786 3’UTR clone of NM_005406 The sequence shown below is from the reference sequence of NM_005406. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTCAAAAATACATCTGGAAAAACTAGTTAACCATGTGACTGAGTGCCCTGTGGAATCGTGTGGGATGCT ACCTGATAAACCAGGCTTCTTTAACCATGCAGAGCAGACAGGCTGTTTCTTTGACACAAATATCACAGG CTTCAGGGTTAAGATTGCTGTTTTTCTGTCCTTGCTTTGGCACAACACACTGAGGGTTTTTTTTATTGC GGGTTTGCCTACAGGTAGATTAGATTAATTATTACTATGTAATGCAAGTACAGTTGGGGGAAAGCTTAG GTAGATATATTTTTTTTAAAAGGTGCTGCCTTTTTGGATTTATAAGAAAATGCCTGTCAGTCGTGATAG AACAGAGTTTTCCTCATATGAGTAAGAGGAAGGGACTTTCACTTTCAAGTGGAACAGCCATCACTATCA AGATCAGCTCATGGAAGGAGTAAAGAAAATATCTCAAAATGAGACAAACTGAAGTTTTGTTTTTTTTTT AATGACTTAAGTTTTTGTGCTCTTGCAAGACTATACAAAACTATTTTAAGAAAGCAGTGATATCACTTG AACTTCAGTGCCCTCACTGTAGAATTTAAAAGCCTTACTGTTGATTGCCCATGTTGGACTTGATGGAGA AATTAAATATCTTTCATTATGCTTTACAAAATACTGTATATGTTTCAGCAAGTTTGGGGAATGGGAGAG GACAAAAAAAAGTTACATTTAATCTATGCATTTTTGCCAAGCCATATTGAGTTATTTTACTACTAGAGA CATTAGGAAACTAACTGTACAAAAGAACCAAGTTTAAAAGCATTTTGTGGGGTACATCATTTCTATAAT TGTATAATGTATTTCTTTGTGGTTTTAAATGATAAAGACATTAAGTTAACAAACATATAAGAAATGTAT GCACTGTTTGAAATGTAAATTATTCTTAGAACACTTTCAATGGGGGTTGCATTGTCCTTTTAGTGCCTT AATTTGAGATAATTATTTTACTGCCATGAGTAAGTATAGAAATTTCAAAAAATGTATTTTCAAAAAATT ATGTGTGTCAGTGAGTTTTTCATTGATAATTGGTTTAATTTAAAATATTTAGAGGTTTGTTGGACTTTC ATAAATTGAGTACAATCTTTGCATCAAACTACCTGCTACAATAATGACTTTATAAAACTGCAAAAAATG TAGAAGGTTGCACCAACATAAAAAGGAAATATGGCAATACATCCATGATGTTTTCCAGTTAACATAGGA ATTACCAGATAAATACTGTTAAACTCTTGTCCAGTAACAAGAGTTGATTCATATGGACAGTATGATTTA TTGTTTATTTTTTTAACCAAATACCTCCTCAGTAATTTATAATGGCTTTGCAGTAATGTGTATCAGATA AGAAGCACTGGAAAACCGATCGTCTCTAGGATGATATGCATGTTTCAAGTGGTATTGAAAGCCGCACTG ATGGATATGTAATAATAAACATATCTGTTATTAATATACTAATGACTCTGTGCTCATTTAATGAGAAAT AAAAGTAATTTATGGATGGGTATCTTTAATTTTTACTGCAATGTGTTTTCTCATGGCTGAAATGAATGG AAAACATACTTCAAATTAGTCTCTGATTGTATATAAATGTTTGTGAAATTCCATGGTTAGATTAAAGTG TATTTTTAAAAGATAAAACGTGGTCTTGGGCTCTAAAACAAGAGTGGGAATAGTTCACATGAAAAGCTG GCTAAAGTGTGTTGGAAAACAATTCTCCATGGGTCTCTTGCATTTCTACACATCAGGGAAGCAGAGGCT CTGACAACCTTTCTTTTGACTATCTTTTCCAAGGATATTTATGTAGTAAACAGCCTTGGAAGATAGAGT TCTCCCTTGTGAGGATGTCGGGTTCTTTTACTGTCCAGTATAATAAAGATAACGTCTCCCACCTATGAT GCAAACCCACTGTGTGCTCAGCACCCACCTGGGCCACTCTGCATTGCCCACATGGGGCTTGGAGGGCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_005406.3
Synonyms	P160ROCK; ROCK-I
Summary	This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Locus ID	6093
MW	77.5

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