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Il17c (NM_145834) Mouse Tagged ORF Clone
CAT＃: MR222634
- TrueORF®
Il17c (Myc-DDK-tagged) - Mouse interleukin 17C (Il17c)
ORF Plasmid: tGFP
"NM_145834" in other vectors (4)
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CNY 2,400.00
CNY 3,705.00
Product images
CNY 300.00
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | IL-17C |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MR222634 representing NM_145834
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGAGTCTCCTGCTTCTAGGCTGGTTGCCTACTGGGATGACCCACCAAGATCCCCCGTCCTGGGGGAAAC CCCGAAGCCATAGGACCCTGCGGTGCTACTCTGCTGAGGAATTATCTCACGGCCAGGCTCCTCCACACCT GCTAACTCGAAGTGCCAGGTGGGAGCAGGCCCTCCCTGTGGCCCTGGTGGCCAGTTTGGAGGCCACGGGC CACAGGAGACAGCATGAAGGACCTCTAGCTGGAACACAGTGCCCCGTGCTGCGGCCGGAGGAGGTGCTGG AAGCTGACACTCACGAGCGCTCCATCTCACCATGGAGATATCGCATCGACACAGATGAGAACCGCTACCC ACAGAAGCTGGCGGTGGCAGAATGCTTGTGTCGTGGATGCATCAACGCCAAGACAGGCCGTGAGACAGCT GCCCTGAACTCGGTGCAGCTGCTGCAGAGCCTGCTGGTACTACGGCGACAGCCCTGCTCCCGAGACGGCA CGGCGGACCCTACACCAGGATCCTTCGCCTTCCACACCGAGTTCATCCGCGTGCCTGTCGGCTGCACCTG CGTTCTTCCCAGGTCTACACAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >MR222634 representing NM_145834
Red=Cloning site Green=Tags(s) MSLLLLGWLPTGMTHQDPPSWGKPRSHRTLRCYSAEELSHGQAPPHLLTRSARWEQALPVALVASLEATG HRRQHEGPLAGTQCPVLRPEEVLEADTHERSISPWRYRIDTDENRYPQKLAVAECLCRGCINAKTGRETA ALNSVQLLQSLLVLRRQPCSRDGTADPTPGSFAFHTEFIRVPVGCTCVLPRSTQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_145834 |
| ORF Size | 582 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_145834.3, NP_665833.3 |
| RefSeq Size | 656 bp |
| RefSeq ORF | 549 bp |
| Locus ID | 234836 |
| UniProt ID | Q8K4C5 |
| MW | 22 kDa |
| Gene Summary | Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NFKB and MAPK pathways. Acts synergically with IL22, TNF and IL1B in inducing antibacterial peptides. May have protective function by maintaining epithelial homeostasis after an inflammatory challenge, such as that caused in the intestine by dextran sulfate sodium in a colitis model. May also promote an inflammatory phenotype, such as skin in a psoriasis model. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases, such as autoimmune encephalitis.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MC212995 | Il17c (untagged) - Mouse interleukin 17C (Il17c), (10ug) |
CNY 2,400.00 |
|
| MG222634 | Il17c (tGFP-tagged) - Mouse interleukin 17C (Il17c), (10ug) |
CNY 2,850.00 |
|
| MR222634L3 | Lenti ORF clone of Il17c (Myc-DDK-tagged) - Mouse interleukin 17C (Il17c) |
CNY 4,750.00 |
|
| MR222634L4 | Lenti ORF clone of Il17c (mGFP-tagged) - Mouse interleukin 17C (Il17c) |
CNY 4,750.00 |
