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TLK2 (NM_006852) Human Untagged Clone
CAT＃: SC115810
TLK2 (untagged)-Human tousled-like kinase 2 (TLK2), transcript variant A
CNY 5,504.00
| Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HsHPK; MRD57; PKU-ALPHA |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_006852 edited
ATGATGGAAGAATTGCATAGCCTGGACCCACGACGGCAGGAATTATTGGAGGCCAGGTTT ACTGGAGTAGGTGTTAGTAAGGGACCACTTAATAGTGAGTCTTCCAACCAGAGCTTGTGC AGCGTCGGATCCTTGAGTGATAAAGAAGTAGAGACTCCCGAGAAAAAGCAGAATGACCAG CGAAATCGGAAAAGAAAAGCTGAACCATATGAAACTAGCCAAGGGAAAGGCACTCCTAGG GGACATAAAATTAGTGATTACTTTGAGTTTGCTGGGGGAAGCGCGCCAGGAACCAGCCCT GGCAGAAGTGTTCCACCAGTTGCACGATCCTCACCGCAACATTCCTTATCCAATCCCTTA CCGCGACGAGTAGAACAGCCCCTCTATGGTTTAGATGGCAGTGCTGCAAAGGAGGCAACG GAGGAGCAGTCTGCTCTGCCAACCCTCATGTCAGTGATGCTAGCAAAACCTCGGCTTGAC ACAGAGCAGCTGGCGCAAAGGGGAGCTGGCCTCTGCTTCACTTTTGTTTCAGCTCAGCAA AACAGTCCCTCATCTACGGGATCTGGCAACACAGAGCATTCCTGCAGCTCCCAAAAACAG ATCTCCATCCAGCACAGACAGACCCAGTCCGACCTCACAATAGAAAAAATATCTGCACTA GAAAACAGTAAGAATTCTGACTTAGAGAAGAAGGAGGGAAGAATAGATGATTTATTAAGA GCCAACTGTGATTTGAGACGGCAGATTGATGAACAGCAAAAGATGCTAGAGAAATACAAG GAACGATTAAATAGATGTGTGACAATGAGCAAGAAACTCCTTATAGAAAAGTCAAAACAA GAGAAGATGGCGTGTAGAGATAAGAGCATGCAAGACCGCTTGAGACTGGGCCACTTTACT ACTGTCCGACACGGAGCCTCATTTACTGAACAGTGGACAGATGGTTATGCTTTTCAGAAT CTTATCAAGCAACAGGAAAGGATAAATTCACAGAGGGAAGAGATAGAAAGACAACGGAAA ATGTTAGCAAAGCGGAAACCTCCTGCCATGGGTCAGGCCCCTCCTGCAACCAATGAGCAG AAACAGCGGAAAAGCAAGACCAATGGAGCTGAAAATGAAACGTTAACGTTAGCAGAATAC CATGAACAAGAAGAAATCTTCAAACTCAGATTAGGTCATCTTAAAAAGGAGGAAGCAGAG ATCCAGGCAGAGCTGGAGAGACTAGAAAGGGTTAGAAATCTACATATCAGGGAACTAAAA AGGATACATAATGAAGATAATTCACAATTTAAAGATCATCCAACGCTAAATGACAGATAT TTGTTGTTACATCTTTTGGGTAGAGGAGGTTTCAGTGAAGTTTACAAGGCATTTGATCTA ACAGAGCAAAGATACGTAGCTGTGAAAATTCACCAGTTAAATAAAAACTGGAGAGATGAG AAAAAGGAGAATTACCACAAGCATGCATGTAGGGAATACCGGATTCATAAAGAGCTGGAT CATCCCAGAATAGTTAAGCTGTATGATTACTTTTCACTGGATACTGACTCGTTTTGTACA GTATTAGAATACTGTGAGGGAAATGATCTGGACTTCTACCTGAAACAGCACAAATTAATG TCGGAGAAAGAGGCCCGGTCCATTATCATGCAGATTGTGAATGCTTTAAAGTACTTAAAT GAAATAAAACCTCCCATCATACACTATGACCTCAAACCAGGTAATATTCTTTTAGTAAAT GGTACAGCGTGTGGAGAGATAAAAATTACAGATTTTGGTCTTTCGAAGATCATGGATGAT GATAGCTACAATTCAGTGGATGGCATGGAGCTAACATCACAAGGTGCTGGTACTTATTGG TATTTACCACCAGAGTGTTTTGTGGTTGGGAAAGAACCACCAAAGATCTCAAATAAAGTT GATGTGTGGTCGGTGGGTGTGATCTTCTATCAGTGTCTTTATGGAAGGAAGCCTTTTGGC CATAACCAGTCTCAGCAAGACATCCTACAAGAGAATACGATTCTTAAAGCTACTGAAGTG CAGTTCCCGCCAAAGCCAGTAGTAACACCTGAAGCAAAGGCGTTTATTCGACGATGCTTG GCCTACCGAAAGGAGGACCGCATTGATGTCCAGCAGCTGGCCTGTGATCCCTACTTGTTG CCTCACATCCGAAAGTCAGTCTCTACAAGTAGCCCTGCTGGAGCTGCTATTGCATCAACC TCTGGGGCGTCCAATAACAGTTCTTCTAATTGA >OriGene 5' read for NM_006852 unedited
CACATTTTGTATACGACTCATATAGGCGGCCGCGAATTCGGCACGAGGCGGCAGCAGAAT GATGGAAGAATTGCATAGCCTGGACCCACGACGGCAGGAATTATTGGAGGCCAGGTTTAC TGGAGTAGGTGTTAGTAAGGGACCACTTAATAGTGAGTCTTCCAACCAGAGCTTGTGCAG CGTCGGATCCTTGAGTGATAAAGAAGTAGAGACTCCCGAGAAAAAGCAGAATGACCAGCG AAATCGGAAAAGAAAAGCTGAACCATATGAAACTAGCCAAGGGAAAGGCACTCCTAGGGG ACATAAAATTAGTGATTACTTTGAGTTTGCTGGGGGAAGCGCGCCAGGAACCAGCCCTGG CAGAAGTGTTCCACCAGTTGCACGATCCTCACCGCAACATTCCTTATCCAATCCCTTACC GCGACGAGTAGAACAGCCCCTCTATGGTTTAGATGGCAGTGCTGCAAAGGAGGCAACGGA GGAGCAGTCTGCTCTGCCAACCCTCATGTCAGTGATGCTAGCAAAACCTCGGCTTGACAC AGAGCAGCTGGCGCAAAGGGGAGCTGGCCTCTGCTTCACTTTTGTTTCAGCTCAGCAAAA CAGTCCCTCATCTACGGGATCTGGCAACACAGAGCATTCCTGCAGCTCCCAAAAACAGAT CTCCATCCAGCACAGACAGACCCAGTCCGACCTCACAATAGAAAAAATATCTGCACTAGA AAACAGTAAGAATTCTGACTTAGAGAAGAAGGAGGGAAGAATAGATGATNTATTAAGAGC CAACTGTGATTTGAGACGGCAGATTGATGAACAGCANAAGATGCTAGAGAAATACAGGNA ACGNATAAATAGATGTGTGACAAATGAGCAGAAACTCCTTATAGAAAAGTCAAAACAAGA GAAAGAGGNCGTGTAGAGAATAGAAGCATGCAAACCGCTTGAGACTGGGCCACTTTACTA CTGTCCGACACG >OriGene 3' read for NM_006852 unedited
CGCGGCCGCAATCTAGTATCGAGTTTTTTTTTTTTTTTTTTGCATGGACAGATGAACCTT TATTTAAAAAAAAGCACTTCAAATAAATTAAAAGGGACAACCGTCAAGTGTTCAAATTGT GAAGAAATAGTTGAAAACCTAGAGAGACTCCAAGCTGCAGTCTTCTAACCTCATTCTTTG TCCAATGGCAAAAACCCACACATCTCAGTACTCCCACTCAATTTTTTCCCTACTGAGATG AGGGAAGCAATTGCAAACAGGAGACCAGACGGAGGAGAAAGCTGCATCTGATTGGAATGA ACATTGCCACGTACTTGCTAATACGGGTTTCACTTTATGACCAAATGTATTCTTTCAAAA ATAAAAAAGGGGAGAGGGAAGCTGCATGTTTTTAAAAATTGAAATTATTTAGGGATAAAA CACTAACTCTAGTGCCTTTAACGGGCAATAGCAACTTTTTTCCTCCGAAGTCAAACACCA TCCCCAGCTGAGCCTTTGTGCTACAAGCTTTTCAGGAGATGTTACCTAAACTTTATTAAA AGAAAAGAACAAGTTTAAATATAGACACTGGACTAGCCCAGTCTGTATTTTCAAGTCCAC ATTCTTCATCTGAAGCACTGCATCAGGGACCCCCCTGAGTCTGCAAGTTTTCAAGTTCAC AGTACATGGAACCAGTTTTTCTTTTTAATTTTTTCCTCACTCAGAGCAGCCACACACAGT GGCCGTTGACGCTGGAACCTCGGGCGGGGCCTTTTCCTACATGGCCTGCNCGGAGCTGCC CAAGGTTNCTCCTCAATGAGAATCGATGCTGTCATGCTCTATGGATGGGNNAAAAGCAGA TATAAAGCACCTGTACAGGTTCATCANACCATTCGGGATCGCTATGTTCAAACCGCTGCT GAACGCATTTGNCACTTTTGTGTGTTGAACAGTTGTGGCCTGAAGTAGNCTCATANAAGA ACGTAATG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_006852 |
| Insert Size | 3270 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_006852.2, NP_006843.2 |
| RefSeq Size | 3616 bp |
| RefSeq ORF | 2253 bp |
| Locus ID | 11011 |
| UniProt ID | Q86UE8 |
| Domains | pkinase, TyrKc, S_TKc |
| Protein Families | Druggable Genome, Protein Kinase |
| Gene Summary | This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Transcript Variant: This variant (A) lacks an alternate in-frame exon in the 3' coding region compared to variant C. The encoded protein (isoform A) is shorter than isoform C. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Amplification of TLK2 Induces Genomic Instability via Impairing the G2-M Checkpoint
,Kim, JA;Anurag, M;Veeraraghavan, J;Schiff, R;Li, K;Wang, XS;,
Mol. Cancer Res.
,PubMed ID 27489360
[TLK2]
|
|
Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers
,Kim, JA;Tan, Y;Wang, X;Cao, X;Veeraraghavan, J;Liang, Y;Edwards, DP;Huang, S;Pan, X;Li, K;Schiff, R;Wang, XS;,
Nat Commun
,PubMed ID 27694828
[TLK2]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC218935 | TLK2 (Myc-DDK-tagged)-Human tousled-like kinase 2 (TLK2), transcript variant A |
CNY 5,496.00 |
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| RC218935L1 | Lenti ORF clone of Human tousled-like kinase 2 (TLK2), transcript variant A, Myc-DDK-tagged |
CNY 7,896.00 |
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| RC218935L2 | Lenti ORF clone of Human tousled-like kinase 2 (TLK2), transcript variant A, mGFP tagged |
CNY 9,790.00 |
|
| RC218935L3 | Lenti ORF clone of Human tousled-like kinase 2 (TLK2), transcript variant A, Myc-DDK-tagged |
CNY 9,790.00 |
|
| RC218935L4 | Lenti ORF clone of Human tousled-like kinase 2 (TLK2), transcript variant A, mGFP tagged |
CNY 9,790.00 |
|
| RG218935 | TLK2 (tGFP-tagged) - Human tousled-like kinase 2 (TLK2), transcript variant A |
CNY 7,096.00 |
|
| SC323426 | TLK2 (untagged)-Kinase deficient mutant (K491M) of Human tousled-like kinase 2 (TLK2), transcript variant A |
CNY 5,504.00 |
|
| SC323565 | TLK2 (untagged)-Kinase deficient mutant (K491M) of Human tousled-like kinase 2 (TLK2), transcript variant A |
CNY 5,504.00 |
