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PML Protein (PML) (NM_033244) Human Untagged Clone
CAT＃: SC128164
PML (untagged)-Human promyelocytic leukemia (PML), transcript variant 5
CNY 4,176.00
CNY 9,030.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | MYL; PP8675; RNF71; TRIM19 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC128164 sequence for NM_033244 edited (data generated by NextGen Sequencing)
ATGGAGCCTGCACCCGCCCGATCTCCGAGGCCCCAGCAGGACCCCGCCCGGCCCCAGGAG CCCACCATGCCTCCCCCCGAGACCCCCTCTGAAGGCCGCCAGCCCAGCCCCAGCCCCAGC CCTACAGAGCGAGCCCCCGCTTCGGAGGAGGAGTTCCAGTTTCTGCGCTGCCAGCAATGC CAGGCGGAAGCCAAGTGCCCGAAGCTGCTGCCTTGTCTGCACACGCTGTGCTCAGGATGC CTGGAGGCGTCGGGCATGCAGTGCCCCATCTGCCAGGCGCCCTGGCCCCTAGGTGCAGAC ACACCCGCCCTGGATAACGTCTTTTTCGAGAGTCTGCAGCGGCGCCTGTCGGTGTACCGG CAGATTGTGGATGCGCAGGCTGTGTGCACCCGCTGCAAAGAGTCGGCCGACTTCTGGTGC TTTGAGTGCGAGCAGCTCCTCTGCGCCAAGTGCTTCGAGGCACACCAGTGGTTCCTCAAG CACGAGGCCCGGCCCCTAGCAGAGCTGCGCAACCAGTCGGTGCGTGAGTTCCTGGACGGC ACCCGCAAGACCAACAACATCTTCTGCTCCAACCCCAACCACCGCACCCCTACGCTGACC AGCATCTACTGCCGAGGATGTTCCAAGCCGCTGTGCTGCTCGTGCGCGCTCCTTGACAGC AGCCACAGTGAGCTCAAGTGCGACATCAGCGCAGAGATCCAGCAGCGACAGGAGGAGCTG GACGCCATGACGCAGGCGCTGCAGGAGCAGGATAGTGCCTTTGGCGCGGTTCACGCGCAG ATGCACGCGGCCGTCGGCCAGCTGGGCCGCGCGCGTGCCGAGACCGAGGAGCTGATCCGC GAGCGCGTGCGCCAGGTGGTAGCTCACGTGCGGGCTCAGGAGCGCGAGCTGCTGGAGGCT GTGGACGCGCGGTACCAGCGCGACTACGAGGAGATGGCCAGTCGGCTGGGCCGCCTGGAT GCTGTGCTGCAGCGCATCCGCACGGGCAGCGCGCTGGTGCAGAGGATGAAGTGCTACGCC TCGGACCAGGAGGTGCTGGACATGCACGGTTTCCTGCGCCAGGCGCTCTGCCGCCTGCGC CAGGAGGAGCCCCAGAGCCTGCAAGCTGCCGTGCGCACCGATGGCTTCGACGAGTTCAAG GTGCGCCTGCAGGACCTCAGCTCTTGCATCACCCAGGGGAAAGATGCAGCTGTATCCAAG AAAGCCAGCCCAGAGGCTGCCAGCACTCCCAGGGACCCTATTGACGTTGACCTGCCCGAG GAGGCAGAGAGAGTGAAGGCCCAGGTTCAGGCCCTGGGGCTGGCTGAAGCCCAGCCTATG GCTGTGGTACAGTCAGTGCCCGGGGCACACCCCGTGCCAGTGTACGCCTTCTCCATCAAA GGCCCTTCCTATGGAGAGGATGTCTCCAATACAACGACAGCCCAGAAGAGGAAGTGCAGC CAGACCCAGTGCCCCAGGAAGGTCATCAAGATGGAGTCTGAGGAGGGGAAGGAGGCAAGG TTGGCTCGGAGCTCCCCGGAGCAGCCCAGGCCCAGCACCTCCAAGGCAGTCTCACCACCC CACCTGGATGGACCGCCTAGCCCCAGGAGCCCCGTCATAGGAAGTGAGGTCTTCCTGCCC AACAGCAACCACGTGGCCAGTGGCGCCGGGGAGGCAGGTAGGGAGAGGAACGCGTTGTGG TGA Clone variation with respect to NM_033244.3 >Reverse primer walk for NM_033244 unedited
CATAACAGGGACCAGCACAACGCGTACGTAAATCCTCGGCAGTACAGCTGGTCAGCGTAG GGGTGCGGTGGTTGGGGTTGGAGCAGAAGAGTTGTTGGTCTTGCGGGTGCCGTCCAGGAA CTCACGCACCGACTGGTTGCGCAGCTCTGCTAGGGGCCGGGCCTCGTGCTTGAGGAACCA CTGGTGTGCCTCGAAGCACTTGGCGCAGAGGAGCTGCTCGCACTCAAAGCACCAGAAGTC GGCCGACTCTTTGCAGCGGGTGCACACAGCCTGCGCATCCACAATCTGCCGGTACACCGA CAGGCGCCGCTGCAGACTCTCGAAAAAGACGTTATCCAGGGCGGGTGTGTCTGCACCTAG GGGCCAGGGCGCCTGGCAGATGGGGCACTGCATGCCCGACGCCTCCAGGCATCCTGAGCA CAGCGTGTGCAGACAAGGCAGCAGCTTCGGGCACTTGGCTTCCGCCTGGCATTGCTGGCA GCGCAGAAACTGGAACTCCTCCTCCGAAGCGGGGGCTCGCTCTGTAGGGCTGGGGCTGGG GCTGGGCTGGCGGCCTTCAGAGGGGGTCTCGGGGGGAGGCATGGTGGGCTCCTGGGGCCG GGCGGNGTCCTGCTGGGGCCTCGGAGATCGGGCGGGTGCAGGCTCCATGGACCCCAGCTT AGTTTCGATTCTCGCTCGTGCCGAATTCGCGGCCGCCCTATAGTGAGTCGTATTACAAAA TTCTGACGGTTCACTAAACGAGCTCTGCTTATATAGACCTCCCACCGTACACGCCTACCG CCCATTTGCGTCAACGGGGCGGGGTTATTACGACATTTTGGAAAGTCCCGTTGATTTTGG TGCCCAAACAAACTCCCATTGACGTCCATGGGGGTGGAGACTTGGAAAATCCCCGTGAGT CAAACCGCTATCCACCG >OriGene 3' read for NM_033244 unedited
GNANGAGCACTGGGGNAGGGTCACAGGGATGCCACCCGGGTTCTGTTCAGGAAAAGCTAT GACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTAAGGCGGACATCTT TATTCAAGCCAGCAAATGACACGCCAGGAGCCCAGGTGAGCCGGAGTGCTCTGCCCAGCC TGGCTGCAGTTGTTGGCCAGAGCTCAGAGCTCTCCTGGGCCTGGCAGATGGCTCTGCCTG CACTTCTTTTTGGGACTCAGAGACTAAATTAGAAAGGGGTGGGGGTAGCCCCAGGAGAAC CCACTTTCATTGTCAATCTTGAGGTCAAAGAAAACCAGAGGTCTGTCTTCTGCTTGGGGG TCAGCAAGGTTCTCGTCCAGGACCCTGAGGGTGCTGGGGCCTTCCAGCTGGAGGTCACTG GACTCACTGCTGCTGTCATCCAGCTCTCGGGAGGACGAGTTTTCGGCATCTGAGTCTTCC GAGCTGCTGATCACCACAACGCGTTCCTCTCCCTACCTGCCTCCCCGGCGCCACTGGCCA CGTGGTTGCTGTTGGGCAGGAAGACCTCACTTCCTATGACGGGGCTCCTGGGGCTAGGCG GTCCATCCAGGTGGGGTGGTGAGACTGCCTTGGAGGTGCTGGGCCTGGGCTGCTCCGGGG AGCTCCGAGCCAACCTTGCCTCCTTCCCCTCCTCAGACTCCATCTTGATGACCTTCCTGG GGCACTGGGTCTGGCTGCACTTCCTCTTCTGGGCTGTCGTTGTATTGGAGACATCCTCTC CATAGGAAGGGCCTTTGATGGAGAAGGCGTACACTGGCACGGGGGTGTGCCCCGGGCACT GACTGTACCACAGCCATAGGCTGGGCTTCAGCCN |
| Restriction Sites | Please inquire |
| ACCN | NM_033244 |
| Insert Size | 2100 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_033244.3, NP_150247.2 |
| RefSeq Size | 3096 bp |
| RefSeq ORF | 1683 bp |
| Locus ID | 5371 |
| UniProt ID | P29590 |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Acute myeloid leukemia, Pathways in cancer, Ubiquitin mediated proteolysis |
| Gene Summary | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (5) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (5, also known as PML-3B, PML-VI and TRIM19epsilon) contains a distinct C-terminus compared to isoform 1. |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC220236 | PML (Myc-DDK-tagged)-Human promyelocytic leukemia (PML), transcript variant 5 |
CNY 4,168.00 |
|
| RC220236L1 | Lenti ORF clone of Human promyelocytic leukemia (PML), transcript variant 5, Myc-DDK-tagged |
CNY 6,460.00 |
|
| RC220236L2 | Lenti ORF clone of Human promyelocytic leukemia (PML), transcript variant 5, mGFP tagged |
CNY 6,460.00 |
|
| RC220236L3 | Lenti ORF clone of Human promyelocytic leukemia (PML), transcript variant 5, Myc-DDK-tagged |
CNY 6,460.00 |
|
| RC220236L4 | Lenti ORF clone of Human promyelocytic leukemia (PML), transcript variant 5, mGFP tagged |
CNY 6,460.00 |
|
| RG220236 | PML (tGFP-tagged) - Human promyelocytic leukemia (PML), transcript variant 5 |
CNY 5,040.00 |
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