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PLCG 2 (PLCG2) (NM_002661) Human Untagged Clone
CAT＃: SC318575
PLCG2 (untagged)-Human phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2)
CNY 14,104.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | APLAID; FCAS3; PLC-gamma-2; PLC-IV |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>SC318575 representing NM_002661.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGTCCACCACGGTCAATGTAGATTCCCTTGCGGAATATGAGAAGAGCCAGATCAAGAGAGCCCTGGAG CTGGGGACGGTGATGACTGTGTTCAGCTTCCGCAAGTCCACCCCCGAGCGGAGAACCGTCCAGGTGATC ATGGAGACGCGGCAGGTGGCCTGGAGCAAGACCGCTGACAAGATCGAGGGCTTCTTGGATATCATGGAA ATAAAAGAAATCCGCCCAGGGAAGAACTCCAAAGATTTCGAGCGAGCAAAAGCAGTTCGCCAGAAAGAA GACTGCTGCTTCACCATCCTATATGGCACTCAGTTCGTCCTCAGCACGCTCAGCTTGGCAGCTGACTCT AAAGAGGATGCAGTTAACTGGCTCTCTGGCTTGAAAATCTTACACCAGGAAGCGATGAATGCGTCCACG CCCACCATTATCGAGAGTTGGCTGAGAAAGCAGATATATTCTGTGGATCAAACCAGAAGAAACAGCATC AGTCTCCGAGAGTTGAAGACCATCTTGCCCCTGATCAACTTTAAAGTGAGCAGTGCCAAGTTCCTTAAA GATAAGTTTGTGGAAATAGGAGCACACAAAGATGAGCTCAGCTTTGAACAGTTCCATCTCTTCTATAAA AAACTTATGTTTGAACAGCAAAAATCGATTCTCGATGAATTCAAAAAGGATTCGTCCGTGTTCATCCTG GGGAACACTGACAGGCCGGATGCCTCTGCTGTTTACCTGCATGACTTCCAGAGGTTTCTCATACATGAA CAGCAGGAGCATTGGGCTCAGGATCTGAACAAAGTCCGTGAGCGGATGACAAAGTTCATTGATGACACC ATGCGTGAAACTGCTGAGCCTTTCTTGTTTGTGGATGAGTTCCTCACGTACCTGTTTTCACGAGAAAAC AGCATCTGGGATGAGAAGTATGACGCGGTGGACATGCAGGACATGAACAACCCCCTGTCTCATTACTGG ATCTCCTCGTCACATAACACGTACCTTACAGGTGACCAGCTGCGGAGCGAGTCGTCCCCAGAAGCTTAC ATCCGCTGCCTGCGCATGGGCTGTCGCTGCATTGAACTGGACTGCTGGGACGGGCCCGATGGGAAGCCG GTCATCTACCATGGCTGGACGCGGACTACCAAGATCAAGTTTGACGACGTCGTGCAGGCCATCAAAGAC CACGCCTTTGTTACCTCGAGCTTCCCAGTGATCCTGTCCATCGAGGAGCACTGCAGCGTGGAGCAACAG CGTCACATGGCCAAGGCCTTCAAGGAAGTATTTGGCGACCTGCTGTTGACGAAGCCCACGGAGGCCAGT GCTGACCAGCTGCCCTCGCCCAGCCAGCTGCGGGAGAAGATCATCATCAAGCATAAGAAGCTGGGCCCC CGAGGCGATGTGGATGTCAACATGGAGGACAAGAAGGACGAACACAAGCAACAGGGGGAGCTGTACATG TGGGATTCCATTGACCAGAAATGGACTCGGCACTACTGCGCCATTGCCGATGCCAAGCTGTCCTTCAGT GATGACATTGAACAGACTATGGAGGAGGAAGTGCCCCAGGATATACCCCCTACAGAACTACATTTTGGG GAGAAATGGTTCCACAAGAAGGTGGAGAAGAGGACGAGTGCCGAGAAGTTGCTGCAGGAATACTGCATG GAGACGGGGGGCAAGGATGGCACCTTCCTGGTTCGGGAGAGCGAGACCTTCCCCAATGACTACACCCTG TCCTTCTGGCGGTCAGGCCGGGTCCAGCACTGCCGGATCCGCTCCACCATGGAGGGCGGGACCCTGAAA TACTACTTGACTGACAACCTCACCTTCAGCAGCATCTATGCCCTCATCCAGCACTACCGCGAGACGCAC CTGCGCTGCGCCGAGTTCGAGCTGCGGCTCACGGACCCTGTGCCCAACCCCAACCCCCACGAGTCCAAG CCGTGGTACTATGACAGCCTGAGCCGCGGAGAGGCAGAGGACATGCTGATGAGGATTCCCCGGGACGGG GCCTTCCTGATCCGGAAGCGAGAGGGGAGCGACTCCTATGCCATCACCTTCAGGGCTAGGGGCAAGGTA AAGCATTGTCGCATCAACCGGGACGGCCGGCACTTTGTGCTGGGGACCTCCGCCTATTTTGAGAGTCTG GTGGAGCTCGTCAGTTACTACGAGAAGCATTCACTCTACCGAAAGATGAGACTGCGCTACCCCGTGACC CCCGAGCTCCTGGAGCGCTACAATATGGAAAGAGATATAAACTCCCTCTACGACGTCAGCAGAATGTAT GTGGATCCCAGTGAAATCAATCCGTCCATGCCTCAGAGAACCGTGAAAGCTCTGTATGACTACAAAGCC AAGCGAAGCGATGAGCTGAGCTTCTGCCGTGGTGCCCTCATCCACAATGTCTCCAAGGAGCCCGGGGGC TGGTGGAAAGGAGACTATGGAACCAGGATCCAGCAGTACTTCCCATCCAACTACGTCGAGGACATCTCA ACTGCAGACTTCGAGGAGCTAGAAAAGCAGATTATTGAAGACAATCCCTTAGGGTCTCTTTGCAGAGGA ATATTGGACCTCAATACCTATAACGTCGTGAAAGCCCCTCAGGGAAAAAACCAGAAGTCCTTTGTCTTC ATCCTGGAGCCCAAGCAGCAGGGCGATCCTCCGGTGGAGTTTGCCACAGACAGGGTGGAGGAGCTCTTT GAGTGGTTTCAGAGCATCCGAGAGATCACCTGGAAGATTGACACCAAGGAGAACAACATGAAGTACTGG GAGAAGAACCAGTCCATCGCCATCGAGCTCTCTGACCTGGTTGTCTACTGCAAACCAACCAGCAAAACC AAGGACAACTTAGAAAATCCTGACTTCCGAGAAATCCGCTCCTTTGTGGAGACGAAGGCTGACAGCATC ATCAGACAGAAGCCCGTCGACCTCCTGAAGTACAATCAAAAGGGCCTGACCCGCGTCTACCCAAAGGGA CAAAGAGTTGACTCTTCAAACTACGACCCCTTCCGCCTCTGGCTGTGCGGTTCTCAGATGGTGGCACTC AATTTCCAGACGGCAGATAAGTACATGCAGATGAATCACGCATTGTTTTCTCTCAATGGGCGCACGGGC TACGTTCTGCAGCCTGAGAGCATGAGGACAGAGAAATATGACCCGATGCCACCCGAGTCCCAGAGGAAG ATCCTGATGACGCTGACAGTCAAGGTTCTCGGTGCTCGCCATCTCCCCAAACTTGGACGAAGTATTGCC TGTCCCTTTGTAGAAGTGGAGATCTGTGGAGCCGAGTATGACAACAACAAGTTCAAGACGACGGTTGTG AATGATAATGGCCTCAGCCCTATCTGGGCTCCAACACAGGAGAAGGTGACATTTGAAATTTATGACCCA AACCTGGCATTTCTGCGCTTTGTGGTTTATGAAGAAGATATGTTCAGCGATCCCAACTTTCTTGCTCAT GCCACTTACCCCATTAAAGCAGTCAAATCAGGATTCAGGTCCGTTCCTCTGAAGAATGGGTACAGCGAG GACATAGAGCTGGCTTCCCTCCTGGTTTTCTGTGAGATGCGGCCAGTCCTGGAGAGCGAAGAGGAACTT TACTCCTCCTGTCGCCAGCTGAGGAGGCGGCAAGAAGAACTGAACAACCAGCTCTTTCTGTATGACACA CACCAGAACTTGCGCAATGCCAACCGGGATGCCCTGGTTAAAGAGTTCAGTGTTAATGAGAACCAGCTC CAGCTGTACCAGGAGAAATGCAACAAGAGGTTAAGAGAGAAGAGAGTCAGCAACAGCAAGTTTTACTCA TAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_002661 |
| Insert Size | 3798 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_002661.4 |
| RefSeq Size | 8707 bp |
| RefSeq ORF | 3798 bp |
| Locus ID | 5336 |
| UniProt ID | P16885 |
| Domains | C2, PI-PLC-X, SH2, SH3, PI-PLC-Y, PH |
| Protein Families | Druggable Genome |
| Protein Pathways | B cell receptor signaling pathway, Calcium signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Glioma, Inositol phosphate metabolism, Leukocyte transendothelial migration, Metabolic pathways, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pathways in cancer, Phosphatidylinositol signaling system, VEGF signaling pathway, Vibrio cholerae infection |
| MW | 147.9 kDa |
| Gene Summary | The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014] |
Documents
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| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200442 | PLCG2 (Myc-DDK-tagged)-Human phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2) |
CNY 7,600.00 |
|
| RC200442L1 | Lenti ORF clone of Human phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2), Myc-DDK-tagged |
CNY 15,608.00 |
|
| RC200442L2 | Lenti ORF clone of Human phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2), mGFP tagged |
CNY 15,608.00 |
|
| RC200442L3 | Lenti ORF clone of Human phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2), Myc-DDK-tagged |
CNY 15,608.00 |
|
| RC200442L4 | Lenti ORF clone of Human phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2), mGFP tagged |
CNY 15,608.00 |
|
| RG200442 | PLCG2 (tGFP-tagged) - Human phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2) |
CNY 14,808.00 |
|
| SC118495 | PLCG2 (untagged)-Human phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2) |
CNY 13,088.00 |
