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MYH (MUTYH) (NM_001048174) Human Untagged Clone
CAT＃: SC319445
MUTYH (untagged)-Human mutY homolog (E. coli) (MUTYH), transcript variant beta3
CNY 3,888.00
CNY 8,360.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | MYH |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_001048174.1
AGCAGTCCTCTGAAGCTTGAGGAGCCTCTAGAACTATGAGCCCGAGGCCTTCCCCTCTCC
CAGAGCGCAGAGGCTTTGAAGGCTACCTCTGGGAAGCCGCTCACCGTCGGAAGCTGCGGG AGCTGAAACTGCGCCATCGTCACTGTCGGCGGCCATGACACCGCTCGTCTCCCGCCTGAG TCGTCTGTGGGCCATCATGAGGAAGCCACGAGCAGCCGTGGGAAGTGGTCACAGGAAGCA GGCAGCCAGCCAGGAAGGGAGGCAGAAGCATGCTAAGAACAACAGTCAGGCCAAGCCTTC TGCCTGTGATGGCCTGGCCAGGCAGCCGGAAGAGGTGGTATTGCAGGCCTCTGTCTCCTC ATACCATCTATTCAGAGACGTAGCTGAAGTCACAGCCTTCCGAGGGAGCCTGCTAAGCTG GTACGACCAAGAGAAACGGGACCTACCATGGAGAAGACGGGCAGAAGATGAGATGGACCT GGACAGGCGGGCATATGCTGTGTGGGTCTCAGAGGTCATGCTGCAGCAGACCCAGGTTGC CACTGTGATCAACTACTATACCGGATGGATGCAGAAGTGGCCTACACTGCAGGACCTGGC CAGTGCTTCCCTGGAGGAGGTGAATCAACTCTGGGCTGGCCTGGGCTACTATTCTCGTGG CCGGCGGCTGCAGGAGGGAGCTCGGAAGGTGGTAGAGGAGCTAGGGGGCCACATGCCACG TACAGCAGAGACCCTGCAGCAGCTCCTGCCTGGCGTGGGGCGCTACACAGCTGGGGCCAT TGCCTCTATCGCCTTTGGCCAGGCAACCGGTGTGGTGGATGGCAACGTAGCACGGGTGCT GTGCCGTGTCCGAGCCATTGGTGCTGATCCCAGCAGCACCCTTGTTTCCCAGCAGCTCTG GGGTCTAGCCCAGCAGCTGGTGGACCCAGCCCGGCCAGGAGATTTCAACCAAGCAGCCAT GGAGCTAGGGGCCACAGTGTGTACCCCACAGCGCCCACTGTGCAGCCAGTGCCCTGTGGA GAGCCTGTGCCGGGCACGCCAGAGAGTGGAGCAGGAACAGCTCTTAGCCTCAGGGAGCCT GTCGGGCAGTCCTGACGTGGAGGAGTGTGCTCCCAACACTGGACAGTGCCACCTGTGCCT GCCTCCCTCGGAGCCCTGGGACCAGACCCTGGGAGTGGTCAACTTCCCCAGAAAGGCCAG CCGCAAGCCCCCCAGGGAGGAGAGCTCTGCCACCTGTGTTCTGGAACAGCCTGGGGCCCT TGGGGCCCAAATTCTGCTGGTGCAGAGGCCCAACTCAGGTCTGCTGGCAGGACTGTGGGA GTTCCCGTCCGTGACCTGGGAGCCCTCAGAGCAGCTTCAGCGCAAGGCCCTGCTGCAGGA ACTACAGCGTTGGGCTGGGCCCCTCCCAGCCACGCACCTCCGGCACCTTGGGGAGGTTGT CCACACCTTCTCTCACATCAAGCTGACATATCAAGTATATGGGCTGGCCTTGGAAGGGCA GACCCCAGTGACCACCGTACCACCAGGTGCTCGCTGGCTGACGCAGGAGGAATTTCACAC CGCAGCTGTTTCCACCGCCATGAAAAAGGTTTTCCGTGTGTATCAGGGCCAACAGCCAGG GACCTGTATGGGTTCCAAAAGGTCCCAGGTGTCCTCTCCGTGCAGTCGGAAAAAGCCCCG CATGGGCCAGCAAGTCCTGGATAATTTCTTTCGGTCTCACATCTCCACTGATGCACACAG CCTCAACAGTGCAGCCCAGTGACACCTCTGAAAGCCCCCATTCCCTGAGAATCCTGTTGT TAGTAAAGTGCTTATTTTTGTAGTTAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_001048174 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001048174.1, NP_001041639.1 |
| RefSeq Size | 1710 bp |
| RefSeq ORF | 1566 bp |
| Locus ID | 4595 |
| UniProt ID | Q9UIF7 |
| Protein Families | Druggable Genome, Stem cell - Pluripotency |
| Protein Pathways | Base excision repair |
| Gene Summary | This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017] Transcript Variant: This variant (beta3), also known as type 2, contains a distinct 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha5. These differences cause translation initiation at a downstream start codon and result in a protein (isoform 4) that is shorter than isoform 5. Variants beta3, gamma3 and beta5 encode the same isoform 4, which has been shown to localize to the nucleus. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC201376 | MUTYH (Myc-DDK-tagged)-Human mutY homolog (E. coli) (MUTYH), transcript variant beta3 |
CNY 3,880.00 |
|
| RC201376L3 | Lenti ORF clone of Human mutY homolog (E. coli) (MUTYH), transcript variant beta3, Myc-DDK-tagged |
CNY 6,370.00 |
|
| RC201376L4 | Lenti ORF clone of Human mutY homolog (E. coli) (MUTYH), transcript variant beta3, mGFP tagged |
CNY 6,370.00 |
|
| RG201376 | MUTYH (tGFP-tagged) - Human mutY homolog (E. coli) (MUTYH), transcript variant beta3 |
CNY 4,940.00 |
