FHIT (NM_002012) Human Mass Spec Standard

Specifications

Product Data
Description	FHIT MS Standard C13 and N15-labeled recombinant protein (NP_002003)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC207120
Predicted MW	16.9 kDa
Protein Sequence	Sequence Link (showhide) >RC207120 protein sequence Red=Cloning site Green=Tags(s) MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVE KHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKHDKEDFPASWRSEEEMAAEAA ALRVYFQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_002003
RefSeq Size	1103
RefSeq ORF	441
Synonyms	AP3Aase; FRA3B
Locus ID	2272
Cytogenetics	3p14.2
Summary	The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Protein Pathways	Non-small cell lung cancer, Purine metabolism, Small cell lung cancer

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