PERK (EIF2AK3) Mouse Monoclonal Antibody [Clone ID: 5G5]

Specifications

Product Data
Clone Name	5G5
Applications	ELISA, WB
Recommend Dilution	ELISA: 1/10000. Western Blot: 1/500 - 1/2000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human EIF2AK3 expressed in E. Coli.
Specificity	Recognizes EIF2AK3
Isotype	IgG1
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	125 kDa
Gene Name	eukaryotic translation initiation factor 2 alpha kinase 3
Database Link	Entrez Gene 9451 Human UniProt ID Q9NZJ5
Background	The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Synonyms	PEK, PERK, HsPEK
Reference Data

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