BCL2 (1-211) Mouse Monoclonal Antibody [Clone ID: AT1B5]

Specifications

Product Data
Clone Name	AT1B5
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA. Western blot (1:250 - 1:500). Immunofluorescence (1:250 - 1:500). Flow cytometry.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human Bcl-2 (1-211aa) purified from E. coli
Specificity	The antibody recognizes Bcl-2 (B-cell lymphoma protein 2 alpha) at aa 1-211.
Isotype	IgG2b
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	B-cell CLL/lymphoma 2
Database Link	Entrez Gene 12043 MouseEntrez Gene 596 Human UniProt ID P10415
Background	Bcl-2 (B-cell lymphoma protein 2 alpha) is an anti-apoptotic protein located primarily in the outer mitochondrial membrane. It blocks the apoptotic death of some cells such as lymphocytes. BCL-2 is thought to regulate cell death by controlling the mitochondrial membrane permeability during apoptosis. Bcl-2 protein has anti-apoptotic functions through inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Synonyms	BCL2, Bcl-2 alpha
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency, Transmembrane
Protein Pathways	Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Focal adhesion, Neurotrophin signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer

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