Nectin2 (extracell. dom.) Rat Monoclonal Antibody [Clone ID: 502-57]

Specifications

Product Data
Clone Name	502-57
Applications	ELISA, IHC, IP, WB
Recommend Dilution	Immunohistochemitry on frozen sections. Flow cytometry: The typical starting working dilution is 1:10. Fixation with PFA or acetone/methanol is recommended. Immunoassays. Immunoprecipitation: The typical starting working dilution is 1:10. Fixation with PFA or acetone/methanol is recommended. Western blot: The typical starting working dilution is 1:10. Fixation with PFA or acetone/methanol is recommended.
Reactivity	Human, Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Extracellular domain of mouse nectin-2
Specificity	This antibody detects Nectin-2 at extracellular domain.
Formulation	PBS Label: FITC State: Liquid Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	FITC
Storage Condition	Store at 2 - 8 °C.
Gene Name	nectin cell adhesion molecule 2
Database Link	Entrez Gene 19294 Mouse UniProt ID P32507
Background	Nectin (originally isolated as poliovirus receptor-related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is colocalized with afadin at cadherin-based cell-cell adherence junctions in various tissues and cell lines. The nectin family consist of nectin-1, nectin-2 and nectin-3. Nectin-2 also known as PRR2 or CD112 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cell lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse nectin-2 leads to infertility of male mice.
Synonyms	Nectin-2, PVRL2, HVEB, PRR2, Nectin-2
Reference Data

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